Physiological and clinical effects of different infusion rates of intravenous fluids for volume expansion: A scoping review.

Purpose: To assess the physiological and clinical effects of different rates of intravenous fluids for volume expansion of critically ill and perioperative patients.

Methods: We searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials for studies comparing intravenous infusion rates both in animals and studies involving healthy subjects, critically ill, and perioperative care patients of all ages.

Results: Seven animal studies, eleven clinical studies and three studies including healthy volunteers were identified.

Evaluation of DNA damage and lipoperoxidation of propofol in patients undergoing elective surgery.

Background And Objectives: Inhaled anaesthetics have been studied regarding their genotoxic and mutagenic potential in vivo. Propofol differs from volatile anaesthetics because it does not show mutagenic effects and it has been reported to be an antioxidant. However, there are no studies with propofol and genotoxicity in vivo.