Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer.

Context: Among the genomic loci harboring potential candidate genes for prostatic cancer (PCa) is the 2q31-33 chromosomal region that harbors the gene encoding phosphodiesterase 11A (PDE11A). In addition, the combined cancer genome expression metaanalysis datasets included PDE11A among the top 1% down-regulated genes in PCa.

Objective: In the present study, we screened 50 unrelated PCa patients of Brazilian descent for PDE11A coding defects.