Publications by authors named "Marcelo Henrique da Cunha Chaves"
Article Synopsis
- The study focuses on developing a non-invasive inhalation method using polycaprolactone nanoparticles to deliver azithromycin for treating respiratory diseases like COVID-19 and pneumonia.
- The nanoparticles were created via an emulsion technique, producing a fine powder formulation that shows high encapsulation efficiency and favorable size for pulmonary delivery.
- Testing revealed the formulation maintains azithromycin’s antimicrobial effectiveness without causing cytotoxicity to human lung cells, indicating potential for improved treatment of lung infections.
Objective: This work aims to evaluate the ability of biorelevant dissolution media to simulate the bioavailability of efavirenz tablets, establish an - relationship (IVIVR) based on data using GastroPlus and simulate formulation changes using DDDPlus™.
Methods: Solubility and drug release profiles were conducted in SLS 0.5% and biorelevant media, such as FaSSIF, FeSSIF, FaSSIF-V2, and FeSSIF-V2.