Publications by authors named "Marcelo Graziano Custodio"
Objective: Oral, low-dose and ultra-low-dose continuous combined 17β-estradiol (E) plus dydrogesterone (D) reduce vasomotor symptoms (VMS) in postmenopausal women.
Methods: Two phase 3, double-blind studies were included. In the European study, postmenopausal women were randomized 2:1:2 to receive E0.
Objectives: Evidence suggests ethnicity-specific differences in postmenopausal symptoms, highlighting the need for therapies that are efficacious across different ethnicities. We evaluated the efficacy of an ultra-low dose combination of 0.5 mg estradiol and 0.
View Article and Find Full Text PDFObjective: Among postmenopausal women, oral, ultra-low-dose continuous combined estradiol (E0.5 mg) plus dydrogesterone (D2.5 mg) reduces vasomotor symptoms (VMS).
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated the safety and tolerability of ultra-low dose estradiol and dydrogesterone among postmenopausal women using data from three clinical trials.
- A total of 1027 participants were analyzed, revealing that the rates of treatment-emergent adverse events (TEAEs) were comparable between the treatment (E0.5/D2.5 mg) and placebo groups.
- While the treatment group saw a higher incidence of breast pain and uterine hemorrhage, the overall conclusion was that the ultra-low dose combination was well tolerated without significant increases in adverse events compared to placebo.
Objectives: To evaluate the molecular testing and treatment patterns in a retrospective cohort of newly diagnosed treatment-naïve patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC).
Methods: This is an observational retrospective cohort study conducted across 10 cancer centers in Brazil. Treatment-naïve patients with locally advanced or metastatic NSCLC were enrolled from January to December 2014.
Objective: The objective of this study was to evaluate maternal and fetal outcome in patients with severe left ventricle systolic dysfunction followed in a tertiary-care hospital.
Methods: We retrospectively evaluated 12 pregnant women with severe systolic dysfunction, defined as a ejection fraction<40%. Follow-up data included functional class evaluation, occurrence of cardiac and obstetric events, labor data and neonatal outcome.