Segmental histomorphometry of the porcine ureter for use as a vascular xenograft.

Purpose: To histologically quantify the different tissues that make up the porcine ureter, (epithelial, connective, and muscular tissue) in the three segments labelled: cranial, middle and caudal, in order to identify the segment most compatible for use as a vascular graft.

Methods: Fifteen porcine ureters were collected, divided into the three segments, and the samples were stained with hematoxylin and eosin, picrosirius red and Weigert's resorcin-fuchsin. The immunohistochemistry technique was applied for alpha-smooth muscle actin.

Metabolism of 2,4-D in plants: comparative analysis of metabolic detoxification pathways in tolerant crops and resistant weeds.

The commercialization of 2,4-D (2,4-dichlorophenoxyacetic acid) latifolicide in 1945 marked the beginning of the selective herbicide market, with this active ingredient playing a pivotal role among commercial herbicides due to the natural tolerance of monocots compared with dicots. Due to its intricate mode of action, involving interactions within endogenous auxin signaling networks, 2,4-D was initially considered a low-risk herbicide to evolve weed resistance. However, the intensification of 2,4-D use has contributed to the emergence of 2,4-D-resistant broadleaf weeds, challenging earlier beliefs.

Use of rainbow trout skin treated with glutaraldehyde as a mesh for abdominal hernioplasty in rats.

Purpose: To test the use of rainbow trout skin as a surgical mesh in abdominal hernioplasties in rats.

Methods: The experiment involved 20 Wistar rats receiving implants of trout skin processed for disinfection in 0.5% glutaraldehyde and preserved in 100% glycerin.

A pilot study on salivary HPV DNA detection to monitor active disease from patients with recurrent respiratory papillomatosis.

Purpose: Recurrent respiratory papillomatosis (RRP) is a human papillomavirus (HPV)-related disease affecting the upper airway and saliva could be an important non-invasive sampling source for viral screening and clinical monitoring. We investigated whether HPV DNA could be detected in saliva (cellular pellets and supernatant) from RRP patients and influence on clinical manifestation of the disease.

Materials And Methods: In this pilot study, saliva samples from 14 RRP patients were obtained in preoperative condition (n = 7) and in disease-free interval (DFI; n = 7).

Nitric oxide-mediated S-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling.

The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and development. Auxin signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) family of transcriptional repressors. Notably, many auxin-modulated physiological processes are also regulated by nitric oxide (NO) that executes its biological effects predominantly through protein S-nitrosylation at specific cysteine residues.

Nontarget-site resistance due to rapid physiological response in 2,4-D resistant Conyza sumatrensis: reduced 2,4-D translocation and auxin-induced gene expression.

Background: Resistance to 2,4-Dichlorophenoxyacetic acid (2,4-D) has been reported in several weed species since the 1950s; however, a biotype of Conyza sumatrensis showing a novel physiology of the rapid response minutes after herbicide application was reported in 2017. The objective of this research was to investigate the mechanisms of resistance and identify transcripts associated with the rapid physiological response of C. sumatrensis to 2,4-D herbicide.

The Deepwater Horizon oil rig accident, 12 years later: analysis focusing on the collective dimension of work and the organizational factors.

The Deepwater Horizon oil rig accident, in 2010, is considered the biggest disaster of the 21st century in the oil and gas industry. A total of 11 workers died, 17 were injured, total loss of the unit, and the largest environmental disaster in the Gulf of Mexico (United States). The existing literature encompasses its environmental, chemical, biological, and economic effects, focusing on immediate causes, that is, situations close to the event in time and space, especially human errors and technical failures.

Identification of a Novel 2,4-D Metabolic Detoxification Pathway in 2,4-D-Resistant Waterhemp ().

A 2,4-dichlorophenoxyactic acid (2,4-D)-resistant population of (common waterhemp) from Nebraska, USA, was previously found to have rapid metabolic detoxification of the synthetic auxin herbicide 2,4-D. We purified the main 2,4-D metabolites from resistant and susceptible plants, solved their structures by nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS), and synthesized the metabolites to determine their toxicity. Susceptible plants conjugated 2,4-D to aspartate to form 2,4-D-aspartic acid (2,4-D-Asp), while resistant plants had a unique metabolic profile where 2,4-D was hydroxylated into 5-OH-2,4-D, followed by conjugation into a sugar metabolite (2,4-D-5--d-glucopyranoside) and subsequent malonylation into 2,4-D-(6'--malonyl)-5--d-glucopyranoside.

Com-On Questionnaire: Development and validation of a questionnaire for evaluating communication skills of oncologists.

Objective: The present study aimed to develop and validate an instrument for assessing the communication skills of oncology physicians from a patient's point of view.

Methods: A first draft of the questionnaire was compiled based on skills reflecting good physician-patient communication identified in the literature. The questionnaire was critically revised by experts to ensure the validity of its contents.

Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics.

The plant hormone auxin acts through regulated degradation of Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) proteins to regulate transcriptional events. In this review, we examine the composition and function of each Aux/IAA structural motif. We then focus on recent characterization of Aux/IAA N-terminal disordered regions, formation of secondary structure within these disordered regions, and post-translational modifications (PTMs) that affect Aux/IAA function and stability.

2,4-D and 2,4-D butoxyethyl ester behavior in Eurasian and hybrid watermilfoil (Myriophyllum spp.).

Background: Hybrid watermilfoil is becoming more prevalent in many lakes where the invasive Eurasian (Myriophyllum spicatum, EWM) and native northern watermilfoil (M. sibiricum) co-occur. These Eurasian and northern watermilfoil hybrids (HWM) grow 30% faster and in many cases are less sensitive to 2,4-dichlorophenoxy acetic acid (2,4-D) than either parent.

Synthetic auxin herbicides: finding the lock and key to weed resistance.

Synthetic auxin herbicides are designed to mimic indole-3-acetic acid (IAA), an integral plant hormone affecting cell growth, development, and tropism. In this review, we explore target site genes in the auxin signaling pathway including SCF, Aux/IAA, and ARFs that are confirmed or proposed mechanisms for weed resistance to synthetic auxin herbicides. Resistance to auxin herbicides by metabolism, either by enhanced cytochrome P450 detoxification or by loss of pro-herbicide activation, is a major non-target-site resistance pathway.

Work fatalities in a Brazilian oil and gas company: analysis of workers' health and safety policy.

This paper aims to discuss the changes in the safety and health policy (SHP) of an oil and gas company from the enlarged accident that occurred in 2001, seeking out to understand the consequences of these changes in the daily activity of workers. It is a mixed study employing an epidemiological data triangulation method, documental research, and qualitative approach. The 2001 oil platform accident (RJ) was considered a milestone in the process of changes in the company's SHP.

Revisiting the P-36 oil rig accident 15 years later: from management of incidental and accidental situations to organizational factors.

The accident with the P-36 oil rig in the Campos Basin in Rio de Janeiro State, Brazil, was one of the petroleum industry's worst international disasters. Based on this specific case, the article aims to (a) verify the role of the human dimension in the reliability of highly complex systems, with a focus on the management of incidental and accidental situations with the potential to lead to large-scale accidents. The analysis should help (b) shed light on some of the organizational factors that can increase the risk level in offshore activities, beyond the so-called immediate causes.

Metabolism of 2,4-dichlorophenoxyacetic acid contributes to resistance in a common waterhemp (Amaranthus tuberculatus) population.

Background: Synthetic auxins such as 2,4-dichlorophenoxyacetic acid (2,4-D) have been widely used for selective control of broadleaf weeds since the mid-1940s. In 2009, an Amaranthus tuberculatus (common waterhemp) population with 10-fold resistance to 2,4-D was found in Nebraska, USA. The 2,4-D resistance mechanism was examined by conducting [ C] 2,4-D absorption, translocation and metabolism experiments.

Fluid-Attenuated Inversion Recovery Vascular Hyperintensities in Patients with Transient Ischemic Attack.

Background: Fluid-attenuated inversion recovery (FLAIR) vascular hyperintensities (FVHs) are common in patients with acute ischemic stroke, possibly representing impaired hemodynamics in the ischemic territory due to intracranial steno-occlusive disease. There are few reports on FVHs in patients with transient ischemic attack (TIA).

Aims: We investigated the prevalence of FVHs and its clinical correlations in patients with TIA.

The influence of patient's knowledge about stroke in Brazil: a cross sectional study.

Unlabelled: Little is known about stroke patients' awareness about the warning signs of stroke and its therapeutic time window in Brazil.

Method: We interviewed consecutive patients with acute stroke admitted to a terciary public hospital in Brazil. Data collected included demographics, mode of arrival, National Institutes of Health Stroke Scale (NIHSS) scores and knowledge of stroke warning signs and therapeutic time window.

Score for atrial fibrillation detection in acute stroke and transient ischemic attack patients in a Brazilian population: the acute stroke atrial fibrillation scoring system.

Objective: Atrial fibrillation is a common arrhythmia that increases the risk of stroke by four- to five-fold. We aimed to establish a profile of patients with atrial fibrillation from a population of patients admitted with acute ischemic stroke or transient ischemic attack using clinical and echocardiographic findings.

Methods: We evaluated patients consecutively admitted to a tertiary hospital with acute ischemic stroke or transient ischemic attack.

Acute foot drop syndrome mimicking peroneal nerve injury: an atypical presentation of ischemic stroke.

Foot drop syndrome is a frequent neurologic condition usually caused by peroneal nerve damage. On rare occasions, foot drop may present as the single neurologic manifestation of intracranial lesions. We presented a 43-year-old man admitted to our hospital with acute weakness in the dorsiflexion of his right foot that appeared 3 days before admission.

Acute stroke: postprocedural care and management of complications.

Endovascular treatment for acute ischemic stroke is an important alternative to thrombolysis with recombinant tissue plasminogen activator (rt-PA) for patients who present beyond the thrombolysis time window, those who are ineligible for rt-PA, or those who do not improve after intravenous rt-PA. These patients generally require special attention in the postprocedural period because, although not frequent, complications of endovascular procedures in acute ischemic stroke have the potential to be devastating. Neurocritical care is essential to reduce and appropriately treat complications after endovascular procedures.

"Meetings on the work": an analysis device for understanding the articulation between outsourcing and other organizational innovations.

The purpose of this article is to discuss professional education and training programs offered to teams of operators by the main company in the area of Bacia de Campos (Petrobras), Rio de Janeiro, Brazil. It also discusses the necessary skills to the new functions derived from the implementation of an organizational innovation, the polyvalence, and how such innovation has impacted operators' activity. By using elements of WEA and the device "Meetings on the Work" it was possible to gain a better understanding of both the distance between the dimensions of prescribed work and real work, and the articulation between outsourcing and the proposition of polyvalence, which have stimulated the creation of new functions, namely, the polyvalent operator and the operator-maintainer, this latter being in fact an evolvement of the first.