Publications by authors named "Marcelo Bordoni"
Corrigendum: Immunization of Experimental Dogs With Salivary Proteins From , Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against .
Front Immunol
August 2019
[This corrects the article DOI: 10.3389/fimmu.2018.
View Article and Find Full Text PDFImmunization of Experimental Dogs With Salivary Proteins From , Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against .
Front Immunol
September 2019
Metacyclic promastigotes are transmitted by sand flies that inject parasites and saliva into the host's skin. Previous studies have demonstrated that DNA plasmids encoding salivary proteins LJM17 and LJL143, when used to immunize dogs, resulted in a systemic and local Th1 cell-mediated immunity that interfered in parasite survival . Here we evaluated the ability of these same salivary antigens to induce anti- immunity and to confer protection by immunizing dogs using a novel vaccination strategy more suitable for use in the field.
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- The study investigates how the parasite load in naturally infected dogs correlates with their ability to infect Lutzomyia longipalpis sand flies, which transmit visceral leishmaniasis.
- No significant differences in parasite load were found based on the clinical manifestations of the dogs, yet nearly half of the infected dogs were still able to infect the sand flies.
- Higher parasite loads in the blood and skin of dogs were positively correlated with the infectiousness to the sand fly vector and the subsequent parasitic load found in the sand flies after feeding.
Host tissues affected by Leishmania infantum have differing degrees of parasitism. Previously, the use of different biological tissues to detect L. infantum DNA in dogs has provided variable results.
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