Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease.

Objective: Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients with cardiovascular disease (CAD) risk.

Methods: A sample of six hundred and forty-seven patients that underwent the coronary angiography in a Cardiac Catheterization Lab was evaluated.

Decrease in coronary flow after consecutive injections of contrast media during coronary angiography.

Background: TIMI frame count (TIMIfc) is widely used to assess coronary flow during angiography and there are studies showing the effects of contrast media on blood cells. In this study, we investigate changes in coronary flow and in red blood cells following contrast injections.

Methods And Results: Coronary flow was assessed by TIMIfc in the left anterior descending and circumflex coronary arteries of patients undergoing elective angiography.