Publications by authors named "Marcelo Antonio Nobrega da Rocha"
Riparin II-type benzamides as novel antibiofilm agents against dermatophytes: chemical synthesis, in vitro, ex vivo and in silico evaluation.
J Antimicrob Chemother
March 2024
Background: The ability of dermatophytes to develop biofilms in host tissues confers physical and biochemical resistance to antifungal drugs. Therefore, research to find new compounds against dermatophyte biofilm is crucial.
Objectives: To evaluate the antifungal activity of riparin II (RIP2), nor-riparin II (NOR2) and dinor-riparin II (DINOR2) against Trichophyton rubrum, Microsporum canis and Nannizzia gypsea strains.
Article Synopsis
- Dermatophytosis is a common fungal infection caused by dermatophytes, which produce biofilms that make treatment difficult due to drug resistance.
- Researchers tested the alkamide alkaloid riparin 1 (RIP1) and its synthetic homologs (NOR1 and DINOR1) for their ability to inhibit biofilm formation in dermatophytes.
- Results showed that RIP1 and NOR1 effectively reduced the viability of biofilms and had antifungal properties, suggesting they could be potential treatments for dermatophytosis.
The ability of dermatophytes to develop biofilms is possibly involved in therapeutic failure because biofilms impair drug effectiveness in the infected tissues. Research to find new drugs with antibiofilm activity against dermatophytes is crucial. In this way, riparins, a class of alkaloids that contain an amide group, are promising antifungal compounds.
View Article and Find Full Text PDF