Publications by authors named "Marcello Imbrizi"

Article Synopsis
  • A study was conducted in Brazil to evaluate the effectiveness and safety of ustekinumab (UST) in treating ulcerative colitis (UC), a condition with limited real-world data in Latin America.
  • The research included 50 patients with moderate-to-severe UC, focusing on their clinical and endoscopic remission after one year of UST treatment; 50% achieved clinical remission, while 36% achieved endoscopic remission.
  • The safety profile revealed that 20% of patients were hospitalized and 18% discontinued the drug mainly due to lack of effectiveness, but the treatment persistence rate at 24 months was 73.7%.
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Background: The most efficient way to prevent complications from inflammatory bowel disease (IBD) is to provide patients with optimized care. Nonetheless, in Brazil, there is no validated methodology for evaluating health services recognized as comprehensive care units (CCU), making it difficult to assess the quality of care provided.

Objective: To understand the current scenario, map the distribution of centers and identify strengths and weaknesses, considering local and regional characteristics.

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Inflammatory Bowel Diseases had their first peak in incidence in countries in North America, Europe, and Oceania and are currently experiencing a new acceleration in incidence, especially in Latin America and Asia. Despite technological advances, 90 years after the development of the first molecule for the treatment of IBD, we still do not have drugs that promote disease remission in a generalized way. We carried out a narrative review on therapeutic advances in the treatment of IBD, the mechanisms of action, and the challenges facing the therapeutic goals in the treatment of IBD.

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Background: Approximately 25% of patients with inflammatory bowel disease (IBD) develop the disease during childhood or adolescence and treatment aims to control active symptoms and prevent long-term complications. The management of Crohn's disease (CD) and ulcerative colitis (UC) can be especially challenging in children and adolescents, related to particularities that may affect growth, development, and puberty.

Objective: This consensus aims to provide guidance on the most effective medical and surgical management of pediatric patients with CD or UC.

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Background: Inflammatory bowel diseases are immune-mediated disorders that include Crohn's disease (CD) and ulcerative colitis (UC). UC is a progressive disease that affects the colorectal mucosa causing debilitating symptoms leading to high morbidity and work disability. As a consequence of chronic colonic inflammation, UC is also associated with an increased risk of colorectal cancer.

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Background: Inflammatory bowel disease (IBD) is an immune-mediated disorder that includes Crohn's disease (CD) and ulcerative colitis. CD is characterized by a transmural intestinal involvement from the mouth to the anus with recurrent and remitting symptoms that can lead to progressive bowel damage and disability over time.

Objective: To guide the safest and effective medical treatments of adults with CD.

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Background: Despite optimized medical therapy, contemporary risk of surgery in inflammatory bowel diseases (IBD) after 10 years of diagnosis is 9.2% in patients with ulcerative colitis (UC) and 26.2% in Crohn's disease, (CD) in the biological era.

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Background: Malnutrition among inflammatory bowel disease (IBD) subjects is well documented in literature and may emerge from factors including inadequate dietary intake, malabsorption and disease activity. The aim of this study was to complete a comprehensive nutrition assessment and explore what possibilities may help bring a better quality of life for IBD subjects.

Methods: Nutritional status based on biochemical tests, body composition and body mass index (BMI).

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Introduction And Objectives: The EncephalApp Stroop Test was developed to more easily diagnose minimal hepatic encephalopathy (MHE). A cut-off of >274.9sec (ONtime+OFFtime) reached a 78% sensitivity and 90% specificity in the validation study, but it has been poorly studied in Brazil.

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Article Synopsis
  • The diagnosis of hepatic focal lesions is complex, as they can arise from various causes, including inflammation, infection, and cancer, with cardiac angiosarcoma being a rare metastatic source.
  • A 26-year-old man presented with respiratory symptoms and abnormal findings, but initial tests failed to identify the underlying issue, leading to an incomplete diagnosis and treatment for tuberculosis.
  • Ultimately, the patient experienced worsening liver lesions and fatal complications, revealing the crucial yet challenging nature of accurately diagnosing liver abnormalities.
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Background/aims: Inflammatory bowel disease (IBD) are chronic entities characterized by local and systemic inflammation and may be associated with thrombosis. The aim of this study was to identify the prevalence of thromboembolic events (TEE) in hospitalized IBD patients and identify risk factors for their occurrence.

Methods: This retrospective, single-center study included patients treated at a Brazilian IBD referral unit between 2004 and 2014.

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Introduction: Bacterial infection is present in up to 30% of hospitalized cirrhotic patients. It can lead, even after its resolution, to organ dysfunction and even acute-on-chronic liver failure (ACLF). It is the precipitating factor of ACLF in one third of the cases and is the main cause of mortality in patients with liver cirrhosis.

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