Publications by authors named "Marcello Ferreti Fanelli"
Article Synopsis
- Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma and relies on angiogenesis, mainly driven by VEGFA and VEGFR2.
- A study was conducted on 168 DLBCL patients and 205 controls to see how certain single nucleotide variants (SNVs) affect DLBCL risk and angiogenic traits.
- Findings revealed that specific genotypes, such as -1154GG, +1192GG with +1719TT, and +1192GG with -2578CC, significantly increased DLBCL risk, while -634GG or GC genotypes were linked to higher levels of blood vessel density and VEGFA.
Objectives: Single nucleotide variants (SNVs) in vascular endothelial growth factor A (VEGFA) and VEGFA receptor (KDR) genes confer different inherited abilities in angiogenesis (AG) pathway. We aimed in the present study to evaluate influence of six VEGFA and four KDR SNVs in clinical features and survival of diffuse large B-cell lymphoma (DLBCL) patients.
Methods: One hundred and sixty-eight DLBCL patients diagnosed between June 2009-September 2014 were enrolled in the study.
Temozolomide (TMZ) is a cytotoxic agent of the imidazotetrazine class, chemically related to dacarbazine. Its use poses higher risks of lymphopenia and opportunistic infections. Prophylaxis for Pneumocystis jiroveci must be considered up to 12 months after treatment discontinuation.
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