Publications by authors named "Marcelle I Cedars"
Objective: To assess the association of systolic and diastolic blood pressure (SBP and DBP) in recently menopausal women with white matter hyperintensity (WMH) volume later in life and determine whether short-term menopausal hormone therapy (mHT) modifies these associations.
Methods: Kronos Early Estrogen Prevention Study (KEEPS) was a multicenter, randomized, double-blinded, placebo-controlled 4-year mHT trial (oral conjugated equine estrogens or transdermal 17β-estradiol). KEEPS continuation was an observational follow-up of the participants 10 years after the end of mHT.
Objective: To investigate if blastocysts originating from different follicular cohorts have variable implantation rates, adjusted for oocyte age, morphology, and/or ploidy.
Design: Retrospective cohort.
Setting: Academic center.
Background: Findings from Kronos Early Estrogen Prevention Study (KEEPS)-Cog trial suggested no cognitive benefit or harm after 48 months of menopausal hormone therapy (mHT) initiated within 3 years of final menstrual period. To clarify the long-term effects of mHT initiated in early postmenopause, the observational KEEPS Continuation Study reevaluated cognition, mood, and neuroimaging effects in participants enrolled in the KEEPS-Cog and its parent study the KEEPS approximately 10 years after trial completion. We hypothesized that women randomized to transdermal estradiol (tE2) during early postmenopause would show cognitive benefits, while oral conjugated equine estrogens (oCEE) would show no effect, compared to placebo over the 10 years following randomization in the KEEPS trial.
View Article and Find Full Text PDFObjective: To investigate if a positive result on ReceptivaDx for evaluation of B-cell lymphoma 6 (BCL6), a proposed marker of progesterone resistance associated with impaired uterine receptivity, correlates with a suboptimal profile of receptivity-associated markers in the window of implantation using the endometrial receptivity array and single-nucleus transcriptomic analysis.
Design: Retrospective clinical cohort study; pilot study of single-nucleus RNA sequencing of prospectively collected window of implantation endometrium undergoing ReceptivaDx BCL6 evaluation.
Setting: Academic center.
Article Synopsis
- The study investigates the impact of maternal COVID-19 infection during pregnancy on the neurodevelopmental outcomes of children at 12, 18, and 24 months of age.
- It utilizes data from the ASPIRE trial, which involved a diverse cohort of over 2,000 pregnant individuals from all states and Puerto Rico, who were enrolled remotely during the pandemic.
- Results show that children exposed to maternal COVID-19 had a higher prevalence of abnormal developmental scores compared to unexposed children, particularly at 12 months, indicating a potential link between the infection and developmental delays.
Purpose Of Review: In this Perspective we share the personal story of a 33-year-old patient diagnosed with metastatic breast cancer and her journey through fertility preservation, surrogacy, and eventually motherhood, highlighting misconceptions about fertility preservation in this population.
Recent Findings: There are nearly 1 million women under the age of 50 diagnosed and living with cancer in the USA. These patients are met with life-altering decisions, including those that may limit their reproductive ability.
Objective: To study the impact of vigorous vs. moderate exercise on metabolic parameters in polycystic ovary syndrome (PCOS).
Design: Randomized controlled trial.
Objective: This study aimed to examine the association between neighborhood poverty and ovarian reserve.
Methods: Among 1,019 healthy premenopausal women in the Ovarian Aging Study, aggregate exposure to neighborhood poverty was examined in relation to biomarkers of ovarian reserve, antimüllerian hormone (AMH) and antral follicle count (AFC). Specifically, the interaction of age-x-neighborhood poverty was assessed cross-sectionally to determine whether AMH and AFC declines across women may be greater in women exposed to more neighborhood poverty.
Article Synopsis
- - The study aimed to explore whether mothers' COVID-19 vaccinations during pregnancy impacted their children's developmental scores at ages 12 and 18 months, focusing on neurodevelopmental outcomes.
- - Conducted through a remote prospective cohort study, it involved 2,487 pregnant individuals from all 50 states, who provided data through the Ages and Stages Questionnaire (ASQ-3) assessing various developmental skills.
- - Results indicated similar rates of developmental delays among infants exposed to maternal COVID-19 vaccination compared to those not exposed, with no statistically significant differences in the outcomes after 12 and 18 months.
Study Objectives: Risk of obstructive sleep apnea (OSA) appears to be increased among patients with polycystic ovary syndrome (PCOS), but the underlying physiology is unclear. We sought to identify predictors of OSA risk among patients with PCOS.
Methods: A cross-sectional analysis of patients evaluated for PCOS at a single tertiary center from 2017-2022 was completed.
Objective: This study aimed to determine long-term cardiometabolic effects of hormone therapies initiated within 3 years of onset of menopause after a 14-year follow-up study of participants of the Kronos Early Estrogen Prevention Study (KEEPS).
Methods: KEEPS was a multisite clinical trial that recruited recently menopausal women with good cardiovascular health for randomization to oral conjugated equine estrogens (Premarin, 0.45 mg/d) or transdermal 17β-estradiol (Climara, 50 μg/d) both with micronized progesterone (Prometrium, 200 mg/d) for 12 d/mo, or placebo pills and patch for 4 years.
Background & Aims: Antimüllerian hormone (AMH) is a marker of ovarian reserve with emerging data linking lower levels to some metabolic and inflammatory diseases in women. Whether AMH levels influence nonalcoholic fatty liver disease (NAFLD) is unknown.
Methods: Leveraging the NASH Clinical Research Network we determined the association of AMH levels within 6 months of liver biopsy with presence and severity of histologic measures of NAFLD in premenopausal women.
Purpose: To analyze the geographic distribution of REI fellowships and clinics across the USA and to strategize ways to improve patient access to care.
Methods: Cross-sectional study using population data obtained from publicly available United States Census Bureau, Society for Assisted Reproductive Technology (SART), and National Resident Matching Program websites. Outcomes include the number of REI clinics, REI fellowship-trained physicians, and REI fellowship programs.
Artificial intelligence, at a simple level, involves the use of a computer that can perform "human" functions: learning from experience, adjusting to new inputs, and simulating human intelligence performing human tasks. This Views and Reviews brings together a diverse group of investigators to evaluate artificial intelligence and the roles it might play in the field of assisted reproductive technology.
View Article and Find Full Text PDFImportance: Fibroids are benign uterine tumors that can cause significant morbidity. Knowledge on fibroid prevalence, especially in the asymptomatic population and in Asian and Hispanic or Latina individuals, is limited, and a better understanding of affected groups will improve timely diagnosis and motivate appropriate recruitment in clinical trials to reduce health disparities.
Objective: To estimate the prevalence of fibroids in a diverse cohort of female individuals.
Objective: To determine whether B-cell lymphoma 6 (BCL6), an endometriosis-associated marker postulated to predict poor pregnancy outcomes, is differentially expressed in the window of implantation with various uterine preparation regimens commonly used for frozen embryo transfers.
Design: A retrospective cohort study.
Setting: An academic center.