Publications by authors named "Marcella Giancoli Kato Cano da Silva"
Breast cancer is the most common cancer in women, but the incidence of mammary carcinoma in female dogs is even higher than in humans. These two tumors have similarities that can be seen by its biological behavior, molecular genetic alterations, and histology. This suggest that female dogs can be an excellent model for preclinical oncological studies.
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- * Researchers isolated cells from fetuses at different gestational ages, finding that the cells maintained fibroblastoid shapes, showed high growth rates, and could differentiate into various types of cells (bone, fat, cartilage).
- * Immunological tests indicated the cells expressed MHC I but not several interleukins or MHC II, and tests in nude mice showed no tumor formation, suggesting AMC cells are promising for low-risk veterinary treatments.