Effects of TachoSil and 5-fluorouracil on colonic anastomotic healing.

Background: The administration of intraperitoneal (IP) 5-fluorouracil (5-FU) during the early postoperative period after cytoreductive surgery can decrease local cancer recurrence but may also cause impairment of the anastomotic healing. This study examined the effects of the use of this therapy and of the anastomotic sealing with TachoSil, a fibrin-thrombin coated sealant (FTCS), on the healing of colon anastomoses.

Materials And Methods: Forty male rats were divided into four groups (1-4, 10 rats each) that underwent transection and anastomosis of the left colon.