Publications by authors named "Marcela Machado"

The objective of the present study was to evaluate the impacts of trichothecenes (Fusarium sporotrichioides) for dairy calves on animal growth, oxidative and inflammatory responses in the presence or absence of essential oils. Twelve calves weaned at 70 days of age were divided into 2 groups: T-C (control) and T-EO (essential oils - oregano, thyme, basil and rosemary) in the period of 40 days consuming ration contaminated by trichothecenes (500 ppb). The animals in the T-EO group received a mixture of EOs via feed at a dosage of 0.

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Vibration signals extracted from structures across diverse health conditions have become indispensable for monitoring structural integrity. These datasets represent a resource for real-time condition monitoring, enabling the precise detection and diagnosis of system anomalies. This paper aims to enrich the scientific community's database on structural dynamics and experimental methodologies pertinent to system modelling.

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Objectives: To compare the effects of four levels of end-expiratory pressure [zero (ZEEP) and three levels of positive end-expiratory pressure (PEEP)] on the cardiovascular system and gas exchange of cats anesthetized with isoflurane and mechanically ventilated for 3 h with a tidal volume of 10 ml/kg.

Study Design: Prospective, randomized, controlled trial.

Animals: Six healthy male neutered purpose-bred cats.

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Objective: To determine the effect of fentanyl on the minimum alveolar concentration of isoflurane (MAC) and cardiovascular variables in dogs, and how the treatment of bradycardia affects them.

Study Design: Prospective, randomized crossover-controlled trial.

Animals: A total of six male Beagle dogs weighing 9.

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Objective: To describe the pharmacokinetics of buprenorphine in dogs following administration of a high-concentration formulation of buprenorphine.

Study Design: Prospective, randomized, crossover study.

Animals: A total of six healthy male intact Beagle dogs, aged 9-13 months and weighing 10.

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Chester step test (CST) estimates the exercise capacity through a submaximal response, which can limit its application in the prescription of exercise. This study aimed to assess whether an adaptation of the CST (with a progressive profile) can have maximal response characteristics in young women and compare it to the incremental shuttle walk test (ISWT). Another aim was to determine its within-day test-retest reliability.

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Objectives: To compare pulmonary gas exchange, tissue oxygenation and cardiovascular effects of four levels of end-expiratory pressure: no positive end-expiratory pressure (ZEEP), positive end-expiratory pressure (PEEP) of maximal respiratory system compliance (PEEPmaxC), PEEPmaxC + 2 cmHO (PEEPmaxC), PEEPmaxC + 4 cmHO (PEEPmaxC), in isoflurane-anesthetized dogs.

Study Design: Prospective randomized crossover study.

Animals: A total of seven healthy male Beagle dogs, aged 1 year and weighing 10.

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This study aims to investigate alleles of the human apolipoprotein E (APOE) and of the angiotensin-converting enzyme (ACE) genes as risk factors for poor quality of sleep in elderly individuals with no major cognitive decline. This cross-sectional, analytical study was conducted with 163 participants aged 75 years in average and 85% female. Sociodemographic, anthropometric and clinical data were gathered, and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth scale, with patient followed for years prior to these evaluations to rule out onset of major mental disorders.

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Objective: To compare the pharmacokinetics of fentanyl at lower (LHR) or higher heart rate (HHR) in dogs anesthetized with isoflurane.

Study Design: Prospective, randomized, crossover controlled trial.

Animals: A group of six healthy 13-month-old male Beagle dogs weighing 9.

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Objectives Three infusion rates of remifentanil were used in isoflurane-anesthetized cats undergoing ovariohysterectomy. The aim of this study was to identify a dosage regimen that would provide optimal anesthetic and surgical conditions, as well as to compare cardiovascular response to surgical stimulation, postoperative analgesia, anesthetic duration and quality of recovery among the tested remifentanil infusion rates. Methods Twenty-seven client-owned, mixed-breed adult healthy female cats were randomized to receive remifentanil 0.

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Abstract The aim of this study was to investigate the influence of ultrasound and high-shear mixing on the properties of microparticles obtained by spray congealing. Dispersions containing 10% carbamazepine and 90% carrier Gelucire® 50/13 (w/w) were prepared using magnetic stirring, high-shear mixing, or ultrasound. Each preparation was made using hot-melt mixing spray congealing to obtain the microparticles.

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Unlabelled: Pompe's disease (PD) is a metabolic myopathy caused by the accumulation of lysosomal glycogen, secondary to acid alpha-glucosidase (GAA) enzyme deficiency. Childhood and late-onset forms are described, differing by the age of onset and symptoms. In this study were analyzed affected siblings with Pompe's disease (PD) and their distinct clinical and pathological presentations.

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