Publications by authors named "Marcela Laurito"
Spontaneous bacterial peritonitis (SBP) is a feared complication of ascites that affects 10%-30% of hospitalized patients with cirrhosis with an associated mortality rate of approximately 20%. Although efforts have been undertaken to encourage prompt evaluation and treatment of SBP, outcomes have generally remained dismal. There is significant interest in identifying factors that can reliably predict mortality among individuals with SBP.
View Article and Find Full Text PDFTransjugular intrahepatic portosystemic shunt (TIPS) is an effective intervention for portal hypertensive complications, but its effect on renal function is not well characterized. Here we describe renal function and characteristics associated with renal dysfunction at 30 days post-TIPS. Adults with cirrhosis who underwent TIPS at 9 hospitals in the United States from 2010 to 2015 were included.
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- Interferon treatment for hepatitis C in liver transplant recipients can lead to immune-mediated graft dysfunction (IGD), with low occurrence rates during direct-acting antiviral (DAA) therapy, reported at 3.4% in a study of HCV+LT patients.
- The study revealed that IGD typically emerged after DAA treatment completion, and many patients exhibited liver enzyme elevations, which were linked to subsequent IGD.
- While IGD is rare, early diagnosis and treatment are essential, as patients with IGD experienced higher rates of complications such as hospitalizations and infections compared to controls.
Background: Insulin resistance and diabetes mellitus are common extrahepatic manifestations of chronic hepatitis C (HCV). Insulin resistance assessed by HOMA-IR is associated with low rates of sustained virological response, especially in HCV genotype 1 positive patients treated with peginterferon/ribavirin. The effect of insulin resistance on sustained virologic response in HCV genotype 3 positive patients who were treated with peginterferon/ribavirin still remains unclear.
View Article and Find Full Text PDFBackground/aims: Controversial results have been found in literature for the association between insulin resistance and sustained virologic response to standard chronic hepatitis C treatment. This study aims to provide a systematic literature review with meta-analysis, in order to evaluate if insulin resistance interferes with sustained virologic response in patients infected by the HCV genotype 1 versus HCV genotypes 2 and 3, undergoing treatment with interferon and ribavirin or pegylated interferon and ribavarin.
Methods: Systematic search was performed on main electronic databases until May 2012.