Publications by authors named "Marcela Forgerini"
Article Synopsis
- Upper gastrointestinal bleeding (UGIB) could be a serious side effect of low-dose aspirin (LDA) use among patients with cardiovascular diseases, prompting this study to explore genetic factors related to this risk.
- The study involved a case-control design with three groups: patients with UGIB using LDA, LDA users without UGIB, and a healthy control group, analyzing specific genetic variants through interviews and blood samples.
- Findings indicated that certain genetic variants (rs2238631 and rs4807491) were linked to a significantly higher risk of UGIB in LDA users, suggesting that genetic testing could help identify individuals at greater risk and guide LDA use in the future.
Article Synopsis
- Forgerini et al. studied the impact of seven genetic variants on the risk of upper gastrointestinal bleeding related to acetylsalicylic acid use in 289 participants, finding no link between these variants and bleeding risk.
- The case-control study involved patients with upper gastrointestinal bleeding and matched controls who used low-dose acetylsalicylic acid, with DNA genotyping performed for specific genetic variants.
- Results showed no significant difference in genetic variant frequencies among low-dose users, but a notable difference was found between the case group and healthy controls for one variant, indicating a complex relationship between genetics and drug reactions.
Background: There is no gold-standard trigger for detecting drug-induced respiratory disorders, a type of Adverse Drug Event (ADE) with high morbimortality, particularly in older people.
Objective: To propose and evaluate the performance of triggers for detecting hospitalizations related to drug-induced respiratory disorders in older people.
Methods: A pilot cross-sectional study was conducted with older people (age ≥ 60) admitted to a Brazilian hospital.
Objective: To identify trigger tools applied to detect adverse drug events (ADEs) in older people and describe their utility and performance.
Methods: A systematic review was conducted in the PubMed, Lilacs, and Scopus databases (January 2024). Studies that developed, applied, or validated trigger tools and evaluated their utility and/or performance for detecting ADEs in older people were considered.
Purpose: To investigate the association between the use of antidepressants and the risk of upper gastrointestinal tract bleeding (UGIB).
Methods: A Case-control study was conducted in a Brazilian hospital complex. Cases were defined as patients with a diagnosis of UGIB and controls as patients admitted for reasons unrelated to gastrointestinal bleeding, gastric concerns, or complications associated with low-dose aspirin (LDA) or nonsteroidal anti-inflammatory drugs (NSAIDs) use.
To investigate whether interindividual variability in the (*2 and *3 alleles) and (rs9923231) genes is associated with increased risk of upper gastrointestinal bleeding (UGIB) in users of non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA). A full case-control study including 200 cases of patients diagnosed with UGIB and 706 controls was conducted in a Brazilian hospital complex. To perform an analysis of NSAIDs dose-effect, the defined daily dose (DDD) for NSAIDs was calculated in the 7-day etiologic window preceding the data index.
View Article and Find Full Text PDFBackground And Aims: Considering the lack of knowledge regarding the influence of the variable number of repeats of 27 pb in intron 4 (4b/4a VNTR - rs61722009) of the endothelial nitric oxide synthase (eNOS) on the drug response, we assessed the influence of this polymorphism for the risk of upper gastrointestinal bleeding (UGIB).
Methods: A case-control study, including 200 cases and 706 controls, was conducted in a Brazilian hospital complex. Cases were participants with UGIB diagnosis.
Background: The use of potentially inappropriate medications (PIMs) for older people is associated with worse health outcomes owing to the occurrence of adverse drug events (ADEs) and drug interactions, leading to increased health care costs.
Objectives: Identify the costs of ADEs related to PIMs use, in addition to the costs predictors.
Methods: A systematic review was conducted in the PubMed and Scopus databases (until February, 2022), and the report of this study was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
Objective: To map explicit screening tools to identify potentially inappropriate medication (PIMs), and the characteristics and limitations of these tools. Including PIMs-interactions, therapeutic alternatives and the clinical management of PIMs.
Methods: A systematic scoping review was conducted in PubMed and Scopus (until May 2021).
Objective: To estimate the prevalence of inadequate vitamin D level and its associated factors for women of childbearing age in Brazil.
Methods: A systematic review was conducted (last updated May 2020). Meta-analyses were performed using the inverse-variance for fixed models with summary proportion calculation by Freeman-Tukey double arcsine.
Background: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak.
Objectives: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors among women of childbearing age, in Brazil.
Design And Setting: Systematic review and meta-analysis conducted at a Brazilian public university.
To assess the association between and variant alleles and the risk to develop upper gastrointestinal bleeding (UGIB) secondary to complicated peptic disease. A case-control study was conducted in a Brazilian complex hospital from July 2016 to March 2020. Patients with UGIB diagnosis.
View Article and Find Full Text PDFBackground: Non-variceal upper gastrointestinal bleeding (NVUGIB) secondary to peptic ulcer disease is a medical digestive emergency and could be one of the most serious adverse drug reactions.
Objective: To identify the frequency of diagnosis of NVUGIB secondary to peptic ulcer disease.
Methods: Prospective and epidemiological study conducted in a tertiary referral Brazilian hospital, from July 2016 to December 2019.
Objective: To map the clinical pharmacy services conducted in Brazil, their characteristics, outcomes, and process measures in general population, as well as the assessment of the clinical impact on people with cardiometabolic diseases (cardiovascular diseases and metabolic diseases).
Methods: A systematic scoping review and meta-analysis were conducted. The electronic searches were re-run in March 2020.
Objectives: To identify drug interactions of potentially inappropriate medications and mental and behavioral disorders, according to explicit potentially inappropriate medications criteria-based tools.
Methodology: A systematic scoping review was conducted in February 2020. Study characteristics, potentially inappropriate medications, drug interactions, rationale, and therapeutic management proposed were extracted.
Non-variceal upper gastrointestinal bleeding (non-variceal UGIB) is a frequent and severe adverse drug reaction. Idiosyncratic responses due to genetic susceptibility to non-variceal UGIB has been suggested. A systematic review was conducted to assess the association between genetic polymorphisms and non-variceal UGIB.
View Article and Find Full Text PDFBackground: Improving knowledge and establishing strategies and policies for better patient safety are worldwide priorities.
Objective: To evaluate drug safety among elderly people with Alzheimer's disease (AD).
Design And Setting: Cross-sectional study among elderly people within the National AD Assistance Protocol (PCDTDA/MS) who were living in the municipality of Araraquara, Brazil, in 2017.
Unlabelled: Dementia is a chronic neurodegenerative disease and Alzheimer's disease (AD) is the most prevalent type.
Objective: To describe the drug monitoring of patients enrolled in a Clinical Protocol and Therapeutic Guidelines of Alzheimer's Disease (PCDTDA) in Brazil.
Methods: A descriptive study based on interviews conducted in 2017 was performed.
Objectives: Evaluate adherence to the therapeutic prophylaxis protocol for venous thromboembolism (VTE) as well as the costs of this practice.
Methods: A descriptive and cross-sectional study was conducted at a State General Hospital in Brazil through reports of drug dispensions, prescriptions and risk stratification of patients. Adherence to the VTE prophylaxis protocol was monitored.
Background: Risks regarding hospital admission due to adverse drug reactions and drug interactions from use of omeprazole have been reported. The question guiding the present review was "Which adverse events occur in patients using omeprazole in a Food and Drug Administration-approved and/or off-label manner?" It was also proposed to evaluate the safety of use of omeprazole.
Design And Setting: Qualitative narrative review with critical evaluation, in a public university.
Brazilian pharmacovigilance regulations involve 3 spheres: health services, Marketing Authorization Holders (MAHs), and sanitary agency. Drug tolerability began to be effectively assessed in Brazil after the founding of the National Agency of Sanitary Surveillance, which developed the Sentinel Network Project. The objective of the Sentinel Network Project is to increase the adverse drug reaction (ADR) reporting rate by health care professionals in the hospital setting.
View Article and Find Full Text PDFDrug administration adjustments for elderly patients with dysphagia: A case report.
Dement Neuropsychol
January 2018
An elderly patient, aged 76 years, diagnosed with dysphagia, depression, hypothyroidism, Alzheimer's disease and mild cognitive deficit, was identified with sertraline and levothyroxine- drug-related problems. Medication Therapy Management (MTM) was used to adjust therapy to the patient's needs by macerating sertraline tablets and solubilizing them in 10-30 mL of orange juice. The patient was advised to take levothyroxine after fasting.
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