Publications by authors named "Marcela Concepcion Caballero Palacios"
Hyaluronan-Mediated Motility Receptor (HMMR) Overexpression Is Correlated with Poor Survival in Patients with B-ALL.
Int J Mol Sci
January 2025
Acute lymphoblastic leukemia (ALL) is a malignant neoplasm with the highest incidence in the pediatric population. Although the 5-year overall survival is greater than 85%, in emerging countries such as Mexico, the mortality rate is high. In Mexico, B-ALL is the most common type of childhood cancer; different characteristics suggest the presence of the disease; however, the prognosis is dependent on clinical and laboratory features, and no adverse prognostic molecular marker for B-ALL has yet been identified.
View Article and Find Full Text PDFv-myb avian myeloblastosis viral oncogene homolog expression is a potential molecular diagnostic marker for B-cell acute lymphoblastic leukemia.
Asia Pac J Clin Oncol
February 2021
Background: B-cell acute lymphoblastic leukemia (B-ALL) is the most commonly diagnosed childhood malignancy worldwide and is especially common in Mexico. Additionally, the number of cases has increased in recent years. Thus, it is very important to develop molecular strategies to diagnose leukemia.
View Article and Find Full Text PDFArticle Synopsis
- B-cell acute lymphoblastic leukemia is the most common cancer in children, especially in Mexico, with over 30% of patients facing relapse and poor outcomes despite a high five-year survival rate.
- Research into gene expression profiles has identified certain transcripts that can help predict disease prognosis, particularly focusing on the ZNF695 gene, which has multiple transcript variants due to alternative splicing.
- In studies, the ZNF695 variants were found to be predominantly expressed in leukemia patients' bone marrow, and notably, the expression levels of long noncoding RNA ZNF695 were linked to survival rates.