Population Pharmacokinetics of Epcoritamab Following Subcutaneous Administration in Relapsed or Refractory B Cell Non-Hodgkin Lymphoma.

Background And Objectives: Epcoritamab is a CD3xCD20 bispecific antibody approved for the treatment of adults with different types of relapsed or refractory (R/R) B cell non-Hodgkin lymphoma (B-NHL) after ≥ 2 lines of systemic therapy. Here we report the first results from a population pharmacokinetic model-based analysis using data from 2 phase 1/2 clinical trials (EPCORE NHL-1, NCT03625037 and EPCORE NHL-3, NCT04542824) evaluating epcoritamab in patients with R/R B-NHL.

Methods: Plasma concentration-time data included 6819 quantifiable pharmacokinetic samples from 327 patients with R/R B-NHL.

Intraoperative, open-heart coronary angiography in severe acute aortic valve endocarditis.

We present the use of intraoperative open-heart coronary angiography in a patient with aortic valve endocarditis and extensive coronary calcification on coronary computed tomography angiography. Open-heart angiography was performed intraoperatively and revealed no significant stenoses. Aortic valve replacement without concomitant bypass surgery was performed, and the patient had an uneventful postoperative course.

Robotic thymectomy in patients with myasthenia gravis: neurological and surgical outcomes.

Objectives: Thymectomy is frequently used in the treatment of myasthenia gravis (MG). But indication, timing or surgical approach remain controversial. This study reports our experiences with robotic thymectomy and surgical and neurological outcomes in a large cohort of patients with MG.