Molecular structures identified in serologically D- samples of an admixed population.

Background: The D- phenotype is mainly caused by the complete deletion of the RHD gene in Caucasians. However, a plethora of allelic variants have been described among D- individuals from different ethnic groups.

Study Design And Methods: A cohort of 1314 routine serologically D- samples from white Argentineans was studied by molecular methods.

Comprehensive analysis of RHD alleles in Argentineans with variant D phenotypes.

Background: The serologic assignment of the RhD status may be hindered in patients with weak D expression. A comprehensive study of RHD alleles occurring in the mixed population of Argentina is necessary to evaluate the most suitable DNA typing strategy.

Study Design And Methods: A total of 18,379 patients from two stratified groups, Group 1 (G1; public hospital) and Group 2 (G2; private laboratory), were RhD phenotyped, and 88 samples with reduced D expression underwent molecular characterization.