[Esthetic repair of crown margins with composite. A case report].

Gingival recessions can cause severe aesthetical problems, especially when associated with the exposure of the margin of crown or bridge restorations. When complete root coverage can not be achieved by periodontal surgery techniques, prosthetic restorations are usually replaced to improve the aesthetic situation. This clinical report describes the application of a composite repair filling as an alternative technique to correct the restoration margin and cover the exposed root surface.

Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement.

Claudins are major components of tight junctions and contribute to the epithelial-barrier function by restricting free diffusion of solutes through the paracellular pathway. We have mapped a new locus for recessive renal magnesium loss on chromosome 1p34.2 and have identified mutations in CLDN19, a member of the claudin multigene family, in patients affected by hypomagnesemia, renal failure, and severe ocular abnormalities.