Accuracy of CAD/CAM-fabricated bite splints: milling vs 3D printing.

Objectives: The aim of this study was to investigate the accuracy of CAD/CAM-fabricated bite splints in dependence of fabrication method (milling vs 3D printing), positioning (horizontal vs vertical), selection of material, and method of deviation measurement.

Materials And Methods: Bite splints were 3D-printed in either horizontal or vertical position (n = 10) using four different resins (Dental LT, Ortho Clear, Freeprint Splint, V-Splint). As control, ten bite splints were fabricated by CNC milling (ProArt CAD Splint).

Prospective Evaluation of a Blood Transfusion Protocol for Patients Undergoing Cardiac Operations.

Background: The Society of Thoracic Surgeons clinical practice guidelines recommend the creation of an interdisciplinary blood management team to implement protocols for improved blood transfusion practices. We report our center's prospective evaluation of a blood transfusion protocol.

Methods: An interdisciplinary blood management team developed protocols for transfusion of packed red blood cells, fresh frozen plasma, platelets, and cryoprecipitate.

Effects of cryolipolysis on abdominal adiposity of women.

Unlabelled: 　　BACKGROUND: The cryolipolysis is on the spotlight as a non-invasive method which reduces fat layer thickness with no damage to surrounding tissues.

Objective: This study aims to verify the effectiveness of cryolipolysis in the reduction of localized adiposity in women.

Materials And Methods: This is an experimental study, without a control group, with pre- and post- treatment evaluation through a single application on the lower abdominal area.

Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery.

Background: Levosimendan is an inotropic agent that has been shown in small studies to prevent or treat the low cardiac output syndrome after cardiac surgery.

Methods: In a multicenter, randomized, placebo-controlled, phase 3 trial, we evaluated the efficacy and safety of levosimendan in patients with a left ventricular ejection fraction of 35% or less who were undergoing cardiac surgery with the use of cardiopulmonary bypass. Patients were randomly assigned to receive either intravenous levosimendan (at a dose of 0.

Aortic valve replacement in a dialysis-dependent Jehovah's Witness: successful use of a minicircuit, microplegia, and multimodality blood conservation technique.

We present the first reported case of an aortic valve replacement operation without blood transfusion in a 62-year-old Jehovah's Witness with dialysis-dependent chronic renal failure, severe anemia, severe aortic stenosis, and symptomatic angina with minimal exertion after an accident in which she suffered fractures of both her right arm and leg. She underwent successful valve replacement surgery after preoperative stabilization of her fractures and high-dose erythropoietin and iron supplement therapy preoperatively and postoperatively. The intraoperative blood conservation technique included a novel approach with a miniature cardiopulmonary bypass circuit and microplegia with limited hemodilution.

[Clinical and epidemiological characteristics of squamous cell carcinoma of the oral cavity in women].

Background: Squamous cell carcinoma (SCC) of the oral cavity occurs mainly in the male population. The objective of the study is to identify the main clinical and epidemiological differences of the oral SCC between men and women.

Methods: Retrospective analysis of the charts of 228 cases of SCC of the oral cavity in women treated at the Head & Neck Surgery Service, Heliopolis Hospital, São Paulo, Brazil from 1977 to 1996.

Adenovirus-mediated expression of a truncated PDGFbeta receptor inhibits thrombosis and neointima formation in an avian arterial injury model.

Platelet-derived growth factor (PDGF) is a major mediator of neointima formation after arterial injury. We constructed a recombinant adenovirus, Ad/PDGFtr, that expresses the soluble extracellular domain of the murine PDGFbeta receptor (PDGFtr). The expressed PDGFtr was appropriately glycosylated and secreted by chicken vascular smooth muscle cells (SMCs) in vitro.

Stable labeled microspheres to measure perfusion: validation of a neutron activation assay technique.

Neutron activation is an accurate analytic method in which trace quantities of isotopes of interest in a sample are activated and the emitted radiation is measured with high-resolution detection equipment. This study demonstrates the application of neutron activation for the measurement of myocardial perfusion using stable isotopically labeled microspheres. Stable labeled and standard radiolabeled microspheres (15 microm) were coinjected in an in vivo rabbit model of myocardial ischemia and reperfusion.

Inflammation and infection imaging with a 99mTc-neutrophil elastase inhibitor in monkeys.

Unlabelled: A radiolabeled human neutrophil elastase inhibitor (EPI-HNE-2) may represent an improved nuclear medicine imaging agent for inflammation and infection. This peptide displays rapid pharmacokinetics due to its low molecular weight and localizes specifically on neutrophil elastase released in inflammatory sites by activated neutrophils.

Methods: In this investigation, the peptide was radiolabeled with 99mTc using N-hydroxysuccinimidyl S-acetylmercaptoacetyltriglycline (NHS-MAG3) as a bifunctional chelator and was administered on 18 occasions to 5 rhesus monkeys with inflammation/infection.

Selective neointimal gene transfer in an avian model of vascular injury.

Avian models of atherosclerosis helped pioneer the study of vascular biology, and offer economic and technical advantages over mammalian models. As an initial step towards investigating important molecular pathways involved in avian atherogenesis and restenosis, we developed a recombinant adenovirus (Ad) which expresses the reporter gene beta-galactosidase (beta-gal), and applied it to cultured chicken vascular smooth muscle cells (SMCs) and a rooster model of acute vascular injury. In cultured chicken SMCs, recombinant gene expression increased as a function of multiplicity of infection (MOI) and incubation time.

Correlations between uptake of technetium-99m Q12 and thallium-201: myocardial perfusion and viability in a model of acute coronary reperfusion.

Unlabelled: To investigate whether Q12 uptake is affected by myocardial viability, as has been noted for 201Tl and sestamibi, we analyzed the initial and delayed distribution patterns of Q12 in a rat coronary artery occlusion-reperfusion model.

Methods: Animals were intubated and ventilated, and their arterial pressures were monitored. A left thoracotomy was performed.

Pharmacokinetics of rocuronium during the three stages of liver transplantation.

Background: Little is known about the influence of liver transplantation on the pharmacokinetics of most anesthetic drugs. The authors determined the pharmacokinetics of rocuronium during liver transplantation and examined whether variability in pharmacokinetics could explain variability in recovery of neuromuscular function.

Methods: Twenty patients undergoing liver transplantation were given rocuronium, 600 microg/kg, after induction of anesthesia and again after perfusion of the transplanted liver.

Duration of rocuronium-induced neuromuscular block during liver transplantation: a predictor of primary allograft function.

The prolongation of vecuronium-induced neuromuscular block has been reported as a predictor of hepatic allograft dysfunction. This study investigates the duration of action of rocuronium, which also relies on hepatic clearance, to examine whether it also is prolonged with allograft dysfunction. Fifty-seven patients undergoing orthotopic liver transplant were given rocuronium (0.

Myocardial uptake of 99mTc-tetrofosmin, sestamibi, and 201Tl in a model of acute coronary reperfusion.

Background: To investigate whether tetrofosmin uptake is affected by myocardial viability as has been noted for 201Tl and sestamibi, we analyzed the initial and delayed distribution patterns of tetrofosmin in a rat coronary artery occlusion-reperfusion model.

Methods And Results: Animals were intubated and ventilated, and their arterial pressures were monitored. A left thoracotomy was performed.

Continuous small-dose aprotinin controls fibrinolysis during orthotopic liver transplantation.

Large doses of aprotinin (1,000,000-2,000,000 kallikrein inhibitor units [KIU] initial dose and a 500,000 KIU/h infusion) have been used during orthotopic liver transplantation (OLT) to reduce the incidence and severity of fibrinolysis. This double-blinded study was designed to investigate whether a small-dose infusion of aprotinin (200,000 KIU/h) would control fibrinolysis. A controlled study was undertaken to compare small-dose aprotinin with a placebo in patients undergoing OLT with veno-venous bypass.

Teboroxime is a marker of reperfusion after myocardial infarction.

Background: It has been shown that serial teboroxime imaging can rapidly assess coronary perfusion in viable myocardial distributions. However, the myocardial uptake of teboroxime after reperfusion of acutely infarcted myocardium has not been critically evaluated. The study object was to assess whether teboroxime uptake in acutely infarcted myocardium is linearly related to blood flow.

Comparison of iodine-125-BMIPP and thallium-201 in myocardial hypoperfusion.

Unlabelled: Radiolabeled fatty acids such as 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) have unique metabolic properties of potential use as myocardial perfusion tracers. Accordingly, we compared the in vivo pattern of uptake of BMIPP and 201Tl in hypoperfused rabbit myocardium.

Methods: Animals were intubated, ventilated and their arterial pressures monitored.

[Sugars and lipids of the clitellum and cocoon albumin in Eisenia fetida Sav (Annelida Oligochaeta)].

Biochemical methods were used to analyze the glucidic and lipidic components of the clitellar epithelium and the cocoon's albumen in Eisenia fetida. In the clitellum, the sugar concentration increased dramatically (about 5-fold) during differentiation. The assays showed increases in several monosaccharides during puberty.

[Analysis of protein nutrient reserves of the clitellum and cocoon albumin in Eisenia fetida Sav (Annelida Oligochaeta). Demonstration of a glycolipoprotein comparable to vitellogenin].

In the clitella of Eisenia fetida, the amount of total proteins decreased dramatically during puberty. In contrast, the level of soluble proteins increased during the same period. In the cocoons, the increase of total proteins and soluble proteins corresponded to the development of the embryos.

[Establishment of a map of neurons in the brain of Eisenia fetida (Annelida, Oligochaeta) containing substances immunologically specific to vertebrate peptides].

Several antisera specific to neuropeptides of vertebrates were applied to sections of the earthworm Eisenia fetida Sav. Some of them were able to reveal specific neurones of the supraoesophageal ganglion: h-GHRF, CRF, Leu- and Met-enkephalin, dynorphin, substance P, CCK-8, and CCK-8S. A map of different areas or nuclei was established in the brain, taking position of reactive cells into account.

[Are cephalic regeration and clitellogenesis controlled by the same neurohormone in the lumbricid, Eisenia foetida?].

The factor which inhibits cephalic regeneration has previously been partially purified. It is a peptidic substance (molecular weight approximately 2 000). On the other hand, the factor responsible for clitellum turgescence is found in the same fractions as the peptidic inhibitory factor.