Publications by authors named "Marc-Antoine Beland"
Introduction: De novo donor-specific HLA antibody (dnDSA) are associated with poor outcomes. Whether this observation applies to both HLA class I and II dnDSA remains unclear.
Methods: We studied 1236 consecutive kidney recipients who had routine anti-HLA antibody surveillance post-transplant.
Article Synopsis
- The development of de novo anti-HLA donor-specific antibodies (dnDSA) in kidney transplant patients is linked to worse transplant outcomes, yet screening for these antibodies post-transplant isn't common.
- Researchers found a correlation between calcineurin inhibitor (tacrolimus) blood levels and the risk of graft loss in patients with dnDSA, suggesting that higher tacrolimus levels are associated with better graft survival.
- The study indicates that monitoring anti-HLA antibodies after transplantation could help optimize immunosuppressive therapy and potentially enhance kidney transplant outcomes.