Publications by authors named "Marc-Andre Breton"
Article Synopsis
- - Recent research has revealed that eukaryotic cells can translate alternative open-reading frames (altORFs) alongside traditional protein coding sequences (CDSs), indicating a broader coding potential than previously recognized.
- - Many of these altORFs code for small proteins that are conserved across various species and contain functional domains, suggesting they have important roles in cellular processes.
- - The discovery of these alternative proteins, such as altMiD51, emphasizes that genes can be multicoding, producing both large and small proteins from a single gene, which may change our understanding of gene function and evolution.
Objective: Ischemia caused by narrowing of femoral artery is a major cause of peripheral arterial disease and morbidity affecting patients with diabetes mellitus. We have previously reported that the inhibition of the angiogenic response to VEGF (vascular endothelial growth factor) in diabetic mice was associated with the increased expression of SHP-1 (SH2 domain-containing phosphatase 1), a protein that can be activated by the AT2 (angiotensin II type 2) receptor. Deletion of AT2 receptor has been shown to promote angiogenesis within the ischemic muscle.
View Article and Find Full Text PDF