Publications by authors named "Marc van Det"

Background Maximum oxygen uptake (VO₂max) is a predictor for postoperative complications after esophagectomy. Cardiopulmonary Exercise Test (CPET) is the golden standard for measuring VO₂max. The alternative Steep Ramp Test (SRT) is less strenuous with several benefits, providing an estimation of VO₂max.

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  • This study evaluates the effectiveness of Robot-assisted minimally invasive esophagectomy (RAMIE) for treating esophageal cancer at various centers globally, aiming to pinpoint areas for enhancement in surgical outcomes.
  • Over three time periods (2016-2023), data from 28 centers was analyzed, revealing improvements in textbook outcome rates, lymph node yields, and decreased hospital stays, particularly with McKeown procedures.
  • The results showed varying success rates in surgical outcomes and complications, with a noteworthy decrease in anastomotic leakage rates and hospital stays over time, highlighting advancements in surgical techniques.
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  • The study aimed to compare recovery quality in esophageal cancer patients receiving two types of pain relief: epidural and paravertebral analgesia, after minimally invasive esophagectomy (MIE).
  • The trial found that while both methods were effective, epidural analgesia provided better quality of recovery in the early postoperative days, though no significant differences were noted on postoperative day 3.
  • Ultimately, both analgesia techniques can be used in practice as they showed similar outcomes regarding complications and hospital stays.
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  • The study investigates the effectiveness of tranexamic acid (TXA) in reducing postoperative bleeding in patients undergoing gastric bypass surgery, particularly in the context of Enhanced Recovery After Bariatric Surgery protocols.
  • This multicenter, double-blind, randomized controlled trial will involve 1,524 participants across six bariatric centers in the Netherlands, comparing the effects of TXA against a placebo.
  • Primary and secondary outcomes will assess hemorrhage rates, surgical details, complications, and costs, with the trial being ethically approved and results planned for publication.
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Importance: Suboptimal surgical performance is hypothesized to be associated with less favorable patient outcomes in minimally invasive esophagectomy (MIE). Establishing this association may lead to programs that promote better surgical performance of MIE and improve patient outcomes.

Objective: To investigate associations between surgical performance and postoperative outcomes after MIE.

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Background: Unnecessary D2-gastrectomy and associated costs can be prevented after detecting non-curable gastric cancer, but impact of staging on treatment costs is unclear. This study determined the cost impact of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and staging laparoscopy (SL) in gastric cancer staging.

Materials And Methods: In this cost analysis, four staging strategies were modeled in a decision tree: (1) FDG-PET/CT first, then SL, (2) SL only, (3) FDG-PET/CT only, and (4) neither SL nor FDG-PET/CT.

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  • This study investigated how different grades of tumor response (TRG) and a new scoring system (TRG-ypN) relate to cancer recurrence and survival in patients with esophageal adenocarcinoma after treatment.
  • The research, which included 2,746 patients treated between 2007 and 2016, found that lower TRG scores corresponded to lower recurrence rates and longer overall survival, with TRG1 patients having better outcomes than those with higher scores.
  • Additionally, residual nodal disease had a more significant negative impact on prognosis compared to remaining disease at the primary tumor site, highlighting the importance of nodal status in treatment outcomes.
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Background: Minimally invasive esophagectomy (MIE) is a technically challenging procedure with a substantial learning curve. Composite volume of upper gastrointestinal (upper GI) procedures for cancer has been previously linked to postoperative outcomes. This study aimed to investigate an association between hospital experience in bariatric surgery and short-term outcomes in MIE.

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Objective: To gain insight into the global practice of robot-assisted minimally invasive gastrectomy (RAMIG) and evaluate perioperative outcomes using an international registry.

Background: The techniques and perioperative outcomes of RAMIG for gastric cancer vary substantially in the literature.

Methods: Prospectively registered RAMIG cases for gastric cancer (≥10 per center) were extracted from 25 centers in Europe, Asia, and South-America.

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Advancements in perioperative care have improved postoperative morbidity and recovery after esophagectomy. The direct start of oral intake can also enhance short-term outcomes following minimally invasive Ivor Lewis esophagectomy (MIE-IL). Subsequently, short-term outcomes may affect long-term survival.

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Background: Anastomotic leak is a severe complication after oesophagectomy. Anastomotic leak has diverse clinical manifestations and the optimal treatment strategy is unknown. The aim of this study was to assess the efficacy of treatment strategies for different manifestations of anastomotic leak after oesophagectomy.

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Background: Laparoscopic surgery has become the golden standard for many procedures, requiring new skills and training methods. The aim of this review is to appraise literature on assessment methods for laparoscopic colorectal procedures and quantify these methods for implementation in surgical training.

Materials And Methods: PubMed, Embase and Cochrane Central Register of Controlled Trials databases were searched in October 2022 for studies reporting learning and assessment methods for laparoscopic colorectal surgery.

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Background: Currently, little is known regarding the optimal technique for the abdominal phase of RAMIE. The aim of this study was to investigate the outcome of robot-assisted minimally invasive esophagectomy (RAMIE) in both the abdominal and thoracic phase (full RAMIE) compared to laparoscopy during the abdominal phase (hybrid laparoscopic RAMIE).

Methods: This retrospective propensity-score matched analysis of the International Upper Gastrointestinal International Robotic Association (UGIRA) database included 807 RAMIE procedures with intrathoracic anastomosis between 2017 and 2021 from 23 centers.

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Introduction: Failure to rescue (FTR) is an important outcome measure after esophagectomy and reflects mortality after postoperative complications. Differences in FTR have been associated with hospital resection volume. However, insight into how centers manage complications and achieve their outcomes is lacking.

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Background: Anastomotic leakage is one of the most life-threatening complications after Ivor Lewis esophagectomy (ILE), with various treatment strategies. Endoscopic techniques are emerging as a less invasive alternative to surgery. Among the current endoscopic techniques, a single placement of an endoluminal nasogastric tube inside the cavity with controlled suction drainage (SD) seems to be an attractive option.

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Conflicting results are reported on the association between post-esophagectomy complications and long-term survival. This multicenter study assesses the association between complications after an esophagectomy and long-term overall survival. Five Dutch high-volume centers collected data from consecutive patients undergoing esophagectomy between 2010 and 2016 and merged these with long-term survival data from the Netherlands Cancer Registry.

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Objective: This study investigated the patterns, predictors, and survival of recurrent disease following esophageal cancer surgery.

Background: Survival of recurrent esophageal cancer is usually poor, with limited prospects of remission.

Methods: This nationwide cohort study included patients with distal esophageal and gastroesophageal junction adenocarcinoma and squamous cell carcinoma after curatively intended esophagectomy in 2007 to 2016 (follow-up until January 2020).

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Objective: To evaluate the learning curve of laparoscopic gastrectomy (LG) after an implementation program.

Background: Although LG is increasingly being performed worldwide, little is known about the learning curve.

Methods: Consecutive patients who underwent elective LG for gastric adenocarcinoma with curative intent in each of the 5 highest-volume centers in the Netherlands were enrolled.

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Background: Anastomotic leak (AL) is a common but severe complication after oesophagectomy. It is unknown how to determine the severity of AL objectively at diagnosis. Determining leak severity may guide treatment decisions and improve future research.

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Purpose: This study aims to (1) quantify physical behavior through self-reports and sensor-based measures, (2) examine the correlation between self-reported and sensor-based physical activity (PA) and (3) assess whether bariatric patients adhere to PA guidelines.

Methods: A Fitbit accelerometer was used to collect minute-to-minute step count and heart rate data for 14 consecutive days. Total physical activity levels (PAL), moderate-to-vigorous intensity physical activity (MVPA) and sedentary behavior (SB) were used to quantify physical behavior.

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Purpose: There is a lack of prospective studies evaluating the effects of body composition on postoperative complications after gastrectomy in a Western population with predominantly advanced gastric cancer.

Methods: This is a prospective side study of the LOGICA trial, a multicenter randomized trial on laparoscopic versus open gastrectomy for gastric cancer. Trial patients who received preoperative chemotherapy followed by gastrectomy with an available preoperative restaging abdominal computed tomography (CT) scan were included.

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Background: The probability of undergoing treatment with curative intent according to the hospital of diagnosis varies for esophagogastric cancer in the Netherlands. Little is known about the factors contributing to this variation. This study aimed to improve the understanding of the differences between the multidisciplinary team meeting treatment proposal and the treatment that was actually carried out and to qualitatively investigate the differences in treatment decision-making after the multidisciplinary team meeting treatment proposal between hospitals.

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Article Synopsis
  • This study analyzed trends in the treatment and outcomes for patients with distal esophageal and gastro-esophageal junction cancers in the Netherlands from 2007 to 2016.
  • It found that the use of transthoracic esophagectomy, neo-adjuvant treatments, and minimally invasive surgery significantly increased during this period.
  • Postoperative results improved, with lower complication rates, higher success in tumor removal, better lymph node retrieval, and longer survival times for patients.
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