Publications by authors named "Marc W Heidorn"
Article Synopsis
- The study investigates the role of autoantibodies (aAbs) against the CXCR3 receptor in cardiovascular disease, suggesting a link between chronic inflammation, autoimmunity, and increased cardiovascular risk.* -
- In a sample of 4195 participants, higher levels of anti-CXCR3 aAbs were associated with thicker arterial walls, increased heart mass, and a higher risk of all-cause mortality, particularly from cardiac causes.* -
- The findings indicate that elevated anti-CXCR3 aAbs may predict serious cardiac events and contribute to heart failure, highlighting their potential significance in cardiovascular health assessments.*
Aims: To establish reference values and clinically relevant determinants for measures of heart rate variability (HRV) and to assess their relevance for clinical outcome prediction in individuals with heart failure.
Methods: Data from the MyoVasc study (NCT04064450; N = 3289), a prospective cohort on chronic heart failure with a highly standardized, 5 h examination, and Holter ECG recording were investigated. HRV markers were selected using a systematic literature screen and a data-driven approach.
Background: The sodium-glucose co-transporter 2 inhibitor empagliflozin improves cardiovascular outcome in patients with type 2 diabetes mellitus (T2DM) and heart failure. Experimental studies suggest a direct cardiac effect of empagliflozin associated with an improvement in left ventricular diastolic function.
Methods: In the randomized, double-blind, two-armed, placebo-controlled, parallel group trial EmDia, patients with T2DM and elevated left ventricular E/E´ ratio were enrolled and randomized 1:1 to receive empagliflozin 10 mg/day versus placebo.
Background: COPD is an established predictor of clinical outcome in patients with chronic heart failure (HF). However, little evidence is available about the predictive value of FEV in chronic HF.
Research Question: Is pulmonary function related to the progression of chronic HF?
Study Design And Methods: The MyoVasc study (ClinicalTrials.
Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of HF. This study aims to investigate sex-specifically the association between PTH concentrations and platelet indices in phenotypes of HF.
View Article and Find Full Text PDFImportance: Global longitudinal strain (GLS) is an emerging echocardiographic biomarker of cardiac function in heart failure (HF). Evidence from large-scale studies comprehensively investigating GLS for its association with clinical phenotypes and mortality in asymptomatic and symptomatic chronic HF is limited.
Objective: To assess the factors associated with GLS and its prognostic value in patients with chronic HF.