New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells.

Background/objectives: The compound (±)- ((4SR,5SR)-4-(hydroxymethyl)-3-methylene-5-octyldihydrofuran-2(3H)-one) is a promising anti-cancer molecule. The enantiomer (-)- displays a potent cytotoxic effect in several tumor cell lines, particularly the ovarian cancer OVCAR-3 cell line, with a 40-fold increase in potency compared with the fatty acid synthase (FAS) inhibitor C75. Furthermore, in vivo, (-)- reduced the tumor burden in neuroblastoma xenografts.