Correlation of Capacitance and Microscopy Measurements Using Image Processing for a Lab-on-CMOS Microsystem.

We present a capacitance sensor chip developed in a 0.35-μm complementary metal-oxide-semiconductor process for monitoring biological cell viability and proliferation. The chip measures the cell-to-substrate binding through capacitance-to-frequency conversion with a sensitivity of 590 kHz/fF.

Real-Time Measurements of Cell Proliferation Using a Lab-on-CMOS Capacitance Sensor Array.

We describe a capacitance sensor array that has been incorporated into a lab-on-CMOS system for applications in monitoring cell viability. This paper presents analytical models, calibration results, and measured experimental results of the biosensor. The sensor has been characterized and exhibits a sensitivity of 590 kHz/fF.