Publications by authors named "Marc Net"
Article Synopsis
- ALDH2 (Aldehyde dehydrogenase 2) is crucial for detoxifying alcohol in the liver but is also linked to various health issues like heart disease, diabetes, neurodegenerative diseases, and aging.
- Research highlights its protective role against oxidative stress and harmful aldehydes in conditions like ischemia reperfusion injury (IRI), which affects several organs but has been less studied in the liver despite ALDH2's abundance there.
- The study reviews how ALDH2 influences pathways involved in IRI and explores therapeutic approaches, including preconditioning strategies and the potential of ALDH2 agonists like Alda-1 to prevent IRI damage during organ transplantation.
During the last decade, hepatocyte transplantation has been suggested as a safe and potentially effective clinical option for the treatment of acute or decompensating chronic liver failure as well as for hereditary liver disease. Currently, one of the major limiting factors for clinical application is the insufficient access to suitable liver cell preparations. In cooperation with the German and Catalane organ procurement organizations, a routine procedure for the isolation of hepatocytes from donor organs rejected for transplantation (n = 117) has been established.
View Article and Find Full Text PDFWe have evaluated the involvement of hepatic preconditioning mediators (adenosine, adenosine A1 and A2 receptors) during normothermic recirculation (NR) in a model of liver transplantation from non-heart-beating donor (NHBD) pigs. Application of NR after 20 min of warm ischemia (WI) reversed the lethal injury associated with transplantation of NHBD livers (achieving 5-day survival and diminishing glutathione S-transferase (GST), aspartate aminotransferase (AST) and hyaluronic acid (HA)). Adenosine administration prior to WI simulated the effect of NR.
View Article and Find Full Text PDFBackground: This study ascertained the effect of S-adenosyl-L-methionine (SAMe) administration on the ischemia-reperfusion injury associated with pig liver transplantation from non-heart-beating donors (NHBDs) after prolonged warm ischemia.
Method: Twenty-five animals underwent transplantation with an allograft from an NHBD. After donor cardiac arrest, cardiopulmonary bypass and normothermic recirculation (NR) were performed for 30 min.