A Phase I Study to Evaluate Two Doses of Wharton's Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease.

Background: Because of their well-described immunosuppressive properties, allogeneic adult human mesenchymal stromal cells (MSC) derived from bone marrow have demonstrated safety and efficacy in steroid refractory acute graft versus host disease (SR aGVHD). Clinical trials have resulted in variable success and an optimal source of MSC has yet to be defined. Based on the importance of maternal-fetal interface immune tolerance, extraembryonic fetal tissues, such as the umbilical cord, may provide an superior tissue source of MSC to mediate immunomodulation in aGVHD.

Vibrational relaxation of NO (v = 1-16) with NO, N2O, NO2, He and Ar studied by time-resolved Fourier transform infrared emission.

Rates of vibrational quenching of NO (v = 1-16) in collisions with a series of quenching species NO, NO2, N2O, He and Ar have been measured at 295 K. NO (v) was formed both by the O(1D) + N2O reaction and the 193 nm photolysis of NO(2), and time-resolved FTIR emission was used to follow the behaviour of the vibrationally excited species. The trends in quenching rate constants can be explained in terms of V-T transfer, V-V transfer and by the effects of competing processes.