Publications by authors named "Marc Martinez de Sarasa Buchaca"
Article Synopsis
- Novel alkyl zinc complexes with acetamidate/thioacetamidate ligands were synthesized and showed varying coordination modes influenced by their electronic and steric properties.
- These complexes were found to effectively catalyze hydroelementation reactions of alkynyl alcohol/acid substrates, leading to enol ether or unsaturated lactone products under mild conditions.
- Kinetic studies revealed that the reactions are first-order with respect to the catalyst and zero-order in alkynyl substrate, while DFT calculations indicated a mechanism involving an alkoxide-zinc intermediate formed through protonolysis of the Zn-alkyl bond.
Article Synopsis
- The reaction of bis(1,2,3-triazol-1-yl)methane derivatives with BuLi and different aldehydes produced new neutral ligand precursors with alcohol groups.
- The characteristics of these compounds varied based on the steric effects of the aldehydes used, with different functionalization patterns observed.
- The resulting precursors were used to create efficient dinuclear organometallic complexes with aluminum and zinc, which demonstrated potential for catalyzing selective polymerization reactions.
Article Synopsis
- The text discusses a method for creating new polymer materials by using ring-opening copolymerization with epoxides, carbon dioxide, and cyclic esters.
- New bimetallic chloride indium complexes are introduced as effective catalysts that work well under mild conditions, producing poly(cyclohexene carbonate) without needing a co-catalyst.
- The process allows for adjustable incorporation of carbon dioxide, leading to different copolymer thermal properties depending on the CO pressure and monomer used.
Article Synopsis
- Nonisocyanate polyurethane materials were created by reacting bis(cyclic carbonates) with various diamines, using 1,4-butanediol bis(glycidyl ether carbonate) as the main starting material.
- The reactions yielded poly(hydroxyurethane) materials efficiently after 16 hours at 80 °C in MeCN, though L-lysine did not react due to its low reactivity; however, the use of strong bases like DBU or TBD allowed for successful reactions, albeit with some unwanted byproducts.
- Characterization of the resulting materials was conducted using various spectroscopic methods (NMR, IR, MALDI-ToF, GPC), and their thermal properties were analyzed, alongside experiments
The catalytic activity and high selectivity reported by bimetallic heteroscorpionate acetate zinc complexes in ring-opening copolymerization (ROCOP) reactions involving CO as substrate encouraged us to expand their use as catalysts for ROCOP of cyclohexene oxide (CHO) and cyclic anhydrides. Among the catalysts tested for the ROCOP of CHO and phthalic anhydride at different reaction conditions, the most active catalytic system was the combination of complex with bis(triphenylphosphine)iminium as cocatalyst in toluene at 80 °C. Once the optimal catalytic system was determined, the scope in terms of other cyclic anhydrides was broadened.
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- Zinc complexes haven't been used as catalysts for hydroalkoxylation of alkynyl alcohols until now, but scorpionate zinc complexes have shown promise.
- A specific zinc amide complex serves as an effective precatalyst, enabling a selective reaction that produces exocyclic enol ethers.
- Kinetic studies reveal that the reaction depends on the catalyst concentration and X-ray and NMR analyses helped identify an alkynyl zinc compound as a crucial intermediate, leading to a proposed catalytic cycle.
Article Synopsis
- Bio-derived cyclic carbonates, including those from terpenes and 10-undecenoic acid, were successfully synthesized using terminal epoxides and CO, achieving high yields.
- A catalyst system allowed for the efficient conversion of an epoxidized fatty acid n-pentyl ester into a cyclic carbonate under mild conditions, with variable cis/trans ratios based on the co-catalyst used.
- Two of the cyclic carbonates were utilized to create non-isocyanate poly(hydroxy)urethanes by reacting with 1,4-diaminobutane.
Article Synopsis
- Researchers developed new bimetallic zinc acetate complexes using heteroscorpionate ligands for the polymerization processes involving cyclohexene oxide and carbon monoxide (CO).
- The synthesized zinc complexes were confirmed through spectroscopy and X-ray diffraction, leading to successful high yields of the compounds.
- The complexes were tested as catalysts, with one particular complex showing high activity for copolymerizing cyclohexene oxide and CO, and further studies led to effective terpolymerization with additional compounds to create polyester-polycarbonate materials.
Article Synopsis
- - Recent studies have investigated the use of the tyrosine kinase inhibitor dasatinib (DAS) for breast cancer treatment, but its low solubility poses challenges for effective delivery and uptake of the drug.
- - Researchers developed biodegradable polyester nanoparticles (NPs) that successfully encapsulate DAS, showing improved drug release profiles and potential for safer clinical use compared to existing delivery methods.
- - The new DAS-loaded nanoparticles demonstrated enhanced therapeutic efficacy against breast cancer without altering the drug's mechanism of action, highlighting their promise as a drug delivery system for further evaluation.
Article Synopsis
- The text discusses the optimization of an organoaluminum catalytic system to enhance the copolymerization of epoxides and anhydrides.
- It analyzes different process variables, including catalysts, cocatalysts, solvents, and substrates, to determine their effects on the copolymerization.
- The findings include kinetic studies, a proposed catalytic mechanism, complete characterization of the produced copolymers, and the introduction of a new copolymer called poly(limonene succinate).