GPIbα-filamin A interaction regulates megakaryocyte localization and budding during platelet biogenesis.

Glycoprotein Ibα (GPIbα) is expressed on the surface of platelets and megakaryocytes (MKs) and anchored to the membrane skeleton by filamin A (flnA). Although GPIb and flnA have fundamental roles in platelet biogenesis, the nature of this interaction in megakaryocyte biology remains ill-defined. We generated a mouse model expressing either human wild-type (WT) GPIbα (hGPIbαWT) or a flnA-binding mutant (hGPIbαFW) and lacking endogenous mouse GPIbα.

Catheter-related thrombosis incidence and risk factors in adult cancer patients with central venous access devices.

Background: Central venous access devices (CVAD) are commonly employed in the management of cancer patients. While having several benefits they are associated with significant risks.

Aim: To review the incidence and risk factors for catheter-related thrombosis (CRT) in cancer patients with a CVAD.