Conditions of retinal glial and inflammatory cell activation after irradiation in a GFP-chimeric mouse model.

Purpose: Microglia cells have been associated with immunologic defense and repair. The course of retinal disease after lethal irradiation for bone marrow depletion and substitution was evaluated with respect to macrophage and microglial involvement.

Methods: Lethal irradiation in C57BL/6 mice was conducted with a low-voltage radiation unit.