Roflumilast for the Treatment of Seborrheic Dermatitis: A Review.

Seborrheic dermatitis (SD) is a chronic inflammatory skin disorder most commonly affecting areas rich in sebaceous glands, such as the scalp, face, axilla, and groin. Several factors can precipitate SD development, such as colonization of Malassezia, sebocyte activity, impaired immunity, and environmental influences. Topical antifungals, corticosteroids, and calcineurin inhibitors are the current mainstay treatment of SD.

The pharmacoeconomics of acne treatment: where are we heading?

Introduction: The increasing recognition of the finite nature of health care resources has prompted the evaluation of the economic impact and value of medical interventions through pharmacoeconomic analysis. Despite the relevance and importance of pharmacoeconomics to dermatologic practice, there is a paucity of available literature on this topic. The purpose of this paper is to assess the number and quality of pharmacoeconomic studies applied to acne therapy as well as to provide a basic understanding of pharmacoeconomic analysis, its application to acne therapy, and the complex factors affecting the study of acne pharmacoeconomics.

Large, nonhealing scalp ulcer associated with scarring alopecia and sclerodermatous change in a patient with porphyria cutanea tarda.

Porphyria cutanea tarda (PCT) is a disorder caused by deficient activity of a liver enzyme that leads to the accumulation of photoactive metabolites in the skin. The initial clinical presentation commonly includes mechanical fragility of the skin and blisters in sun-exposed areas. Sclerodermatous skin changes and scarring alopecia are described in up to 20% of patients.