Publications by authors named "Marc Hazeu"
Glycosphingolipids (GSLs) fulfil diverse functions in cells. Abnormalities in their metabolism are associated with specific pathologies and, consequently, the pharmacological modulation of GSLs is considered a therapeutic avenue. The accurate measurement of in situ metabolism of GSLs and the modulatory impact of drugs is warranted.
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- Deficiency in the enzyme glucocerebrosidase (GBA) leads to Gaucher disease, which affects cholesterol metabolism and the breakdown of certain lipids.
- Research shows that recombinant human GBA can also cleave β-xylosides and transxylosylate cholesterol, producing a new compound, di-xylosyl-cholesterol (XylChol), which is reduced in patients with Gaucher disease.
- The study identifies xylosylated ceramide (XylCer) as a potential donor for the formation of XylChol, suggesting that food-derived β-D-xylosides and XylCer might play a role in lipid metabolism in cells.
Classical drug design and development rely mostly on affinity- or potency-driven structure-activity relationships (SAR). Thus far, a given compound's binding kinetics have been largely ignored, the importance of which is now being increasingly recognized. In the present study, we performed an extensive structure-kinetics relationship (SKR) study in addition to a traditional SAR analysis at the adenosine A2A receptor (A2A R).
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