Low rectal resection for low rectal endometriosis and rectal adenocarcinoma: Are we discussing the same risks?

Objective: To evaluate the rate and risk factors for anastomosis leakage in patients undergoing colorectal resection with low anastomosis for rectal endometriosis and rectal adenocarcinoma.

Methods: A retrospective cohort study evaluating prospectively collected data was conducted. Patients undergoing colorectal resection for rectal endometriosis and rectal adenocarcinoma with low anastomosis (<7 cm from the anal verge [AV]) from September 2018 to January 2023 were included in the analysis.

Degradation Measurement and Modelling under Ageing in a 16 nm FinFET FPGA.

Most of the latest generation of integrated circuits use FinFET transistors for their performance, but what about their reliability? Does the architectural evolution from planar MOSFET to FinFET transistor have any effect on the integrated circuit reliability? In this article, we present a test bench we have developed to age and measure the degradation of 5103 ring oscillators (ROs) implemented in nine FPGAs with 16nm FinFET under different temperature and voltage conditions (Vnom≤Vstress≤1.3Vnom and 25°C≤Tstress≤115°C) close to operational conditions in order to predict reliability regarding degradation mechanisms at the transistor scale (BTI, HCI and TDDB) as realistically as possible. By comparing our initial RO measurements and the data extracted from Vivado, we will show that the performance of the nine FPGAs is between 50% and 70% of the best performance expected by Vivado.

Robotic Management of Recurrent Rectal Endometriosis After Previous Segmental Bowel Resection.

Objective: To describe the management of recurrent bowel endometriosis after previous colorectal resection.

Design: Surgical video article. The local institutional board review was omitted due to the narration of surgical management.

How are Autistic People Involved in the Design of Extended Reality Technologies? A Systematic Literature Review.

The primary aim of this systematic review is to investigate the inclusion of autistic individuals in the design process of immersive technologies. This study follows the preferred reporting items for systematic reviews and meta-analyses standards for systematic literature reviews. To ensure the research questions and subsequent stages of the review incorporate pertinent parameters, the problem, interest, context framework has also been employed.

Excision of Deep Rectovaginal Endometriosis Nodules with Large Infiltration of Both Rectum and Vagina: What Is a Reasonable Rate of Preventive Stoma? A Comparative Study.

Study Objective: To compare postoperative complications and rectovaginal fistula rate in women undergoing excision of large rectovaginal endometriosis requiring concomitant excision of rectum and vagina during 2 time periods with differing policies for preventive stoma confection.

Design: Retrospective before-and-after comparative cohort study on data prospectively recorded in a database. Patients managed from September 2018 to March 2020 (first period) were compared with those managed from April 2020 to June 2022 (second period).

Disk Excision Using End-to-End Anastomosis Circular Stapler for Deep Endometriosis of the Rectum: A 492-Patient Continuous Prospective Series.

Study Objective: To report a large series including women managed by disk excision using end-to-end anastomosis (EEA) circular transanal stapler to assess the feasibility of the technique, the features of nodules suitable for removal by disk excision, and the rate of major early complications.

Design: Retrospective study on data prospectively recorded in 2 databases.

Setting: Two tertiary referral centers.

Natural Orifice Specimen Extraction Colorectal Resection for Deep Endometriosis: A 50 Case Series.

Study Objective: To describe our experience with the use of natural orifice specimen extraction (NOSE) technique for segmental bowel resection in patients with colorectal endometriosis.

Design: A retrospective, observational study.

Setting: A single tertiary referral center.

A Nitrite Excipient Database: A Useful Tool to Support N-Nitrosamine Risk Assessments for Drug Products.

N-Nitrosamine risk assessment and control have become an integral part of pharmaceutical drug product development and quality evaluation. Initial reports of nitrosamine contamination were linked with the drug substance and its manufacturing process. Subsequently, the drug product and aspects of the formulation process have shown to be relevant.

High speed e-beam lithography for gold nanoarray fabrication and use in nanotechnology.

E-beam lithography has been used for reliable and versatile fabrication of sub-15 nm single-crystal gold nanoarrays and led to convincing applications in nanotechnology. However, so far this technique was either too slow for centimeter to wafer-scale writing or fast enough with the so-called dot on the fly (DOTF) technique but not optimized for sub-15 nm dots dimension. This prevents use of this technology for some applications and characterization techniques.

Ultracompact optical filter based on a stub resonator in GaInAsP/InP optical wire technology.

We report on the fabrication and characterization of a very compact filtering structure based on a resonant stub fabricated using optical wire technology in the InP material line. The stub length is close to 1.6 microm and has been designed to get a resonance wavelength close to 1550 nm.

Design, optimization and fabrication of an optical mode filter for integrated optics.

We present the design, optimization, fabrication and characterization of an optical mode filter, which attenuates the snaking behavior of light caused by a lateral misalignment of the input optical fiber relative to an optical circuit. The mode filter is realized as a bottleneck section inserted in an optical waveguide in front of a branching element. It is designed with Bézier curves.

Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment.

Long-acting parenteral formulations of antiretrovirals could facilitate maintenance and prophylactic treatment in HIV. Using the poorly water- and oil-soluble non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278 (rilpivirine) as base or hydrochloride (HCl), nanosuspensions were prepared by wet milling (Elan NanoCrystal technology) in an aqueous carrier. Laser diffraction showed that the average particles size were (1) close to the targeted size proportionality (200-400-800 nm), with increasing distributions the larger the average particle size, and (2) were stable over 6 months.

Pharmacokinetics of tipifarnib after oral and intravenous administration in subjects with advanced cancer.

The primary objective of this study was to identify intravenous regimens of tipifarnib that would mimic the systemic exposure obtained after the current twice-daily oral administration of tipifarnib. After determination of an intravenous dose that 6 subjects with advanced cancer could tolerate, another 26 subjects were randomly assigned to receive 3 consecutive 4-day regimens of tipifarnib with different treatment sequences: a 100-mg 2-hour intravenous infusion, 200-mg oral administration twice daily, and a 200-mg/d continuous intravenous infusion. The systemic exposure to tipifarnib was comparable among these 3 regimens.

[Emphysematous cystitis complicating non-conservative total hysterectomy for ovarian cancer].

The authors report a case of emphysematous cystitis in a 50-year-old woman treated by corticosteroids, occurring 1 month after hysterectomy for locally advanced ovarian cancer. Although the patient presented a vesico-vaginal fistula, the presence of air in the bladder wall and only in the bladder lumen, confirmed the diagnosis of emphysematous cystitis. Despite intensive care and surgery with colostomy and Mikulicz drainage associated with urinary diversion (transparietal bladder catheter on one side and cutaneous ureterostomy on the other side), the patient died on day 10 in a context of sepsis.

A mucoadhesive, cyclodextrin-based vaginal cream formulation of itraconazole.

The development of vaginal medications, especially antifungal medications, requires that the drug is solubilized as well as retained at or near the mucosa for sufficient periods of time to ensure adequate bioavailability. Itraconazole is a broad-spectrum antifungal agent, which has been used for some time orally and intravenously but for which a vaginal formulation has not yet been developed. We present here a novel itraconazole formulation intended for vaginal use based on hydroxypropyl-beta-cyclodextrin (HPbetaCD), a functional excipient that increases drug solubility and generates a mucoadhesive system in the presence of other ingredients.