Publications by authors named "Marc De Benedetti"
This study assessed the comparative efficacy of lisocabtagene maraleucel (liso-cel) in PILOT (NCT03483103), an open-label, phase II study, versus conventional second-line (2L) chemotherapy regimens in the real world administered to patients with relapsed or refractory (R/R) large B-cell lymphoma (LBCL) who were not intended for hematopoietic stem cell transplantation (HSCT). The liso-cel-treated cohort (n=61) was based on patients who received liso-cel in the PILOT study. The conventional chemotherapy cohort included patients who met PILOT eligibility criteria and received conventional 2L chemotherapy in the real-world clinical setting (n=273).
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- * The research matched the characteristics of real-world patients to those in the TRANSCEND study to create a balanced analytic cohort.
- * Results showed that patients treated with liso-cel had significantly better outcomes than those receiving conventional therapies, including higher overall response rates (74% vs 39%), complete response rates (50% vs 24%), and longer median overall survival (23.5 vs 6.8 months).
Representation of Spatial Variability of the Water Fluxes over the Congo Basin Region.
Sensors (Basel)
December 2021
Article Synopsis
- The Congo Basin plays a crucial role in the global climate but is not well understood due to limited data and difficult validation methods.
- This study employs the Decorrelation Length Scale (DLCS) technique to analyze how model resolution affects the spatial variability of hydroclimate elements—specifically precipitation (P), evaporation/evapotranspiration (E), and the difference between them (P-E).
- Findings indicate that the sensitivity of P and P-E to model resolution varies, with P showing significant spatial variability over land and the equatorial Atlantic, while E exhibits more uniform characteristics across resolutions.