Publications by authors named "Marc Buse"
Article Synopsis
- Tubular injury is a key problem in acute kidney injury (AKI) that affects both patients and healthcare systems.
- Researchers created special mice to study how certain kidney cells change during injury and can return to normal after healing.
- The study found that these injured cells can revert back to their healthy state once the injury is treated, showing that the kidney has a way to adapt and recover.
Background: Glucocorticoids are the treatment of choice for proteinuric patients with minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS). Immunosuppressive as well as direct effects on podocytes are believed to mediate their actions. In this study, we analyzed the anti-proteinuric effects of inhibition of the glucocorticoid receptor (GR) in glomerular epithelial cells, including podocytes.
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- - Acute kidney injury (AKI) is a serious health issue that leads to high rates of illness and death, with currently no specific treatments beyond supportive care.
- - Single-cell technologies have advanced our understanding of the genetic activities within specific cell types of the kidney, which is crucial for grasping how AKI develops and progresses to chronic kidney disease.
- - This review aims to summarize and discuss significant findings related to AKI, highlighting the insights gained from single-cell approaches in kidney research.