Publications by authors named "Marc Brazie"

Article Synopsis
  • The experiments investigated how phosphate transport in cultured mouse proximal tubule cells is influenced by parathyroid hormone (PTH), dopamine, and various signaling molecules.
  • Both PTH and dopamine were found to decrease phosphate transport by over 30%, with the effect of PTH being dependent on protein kinase C (PKC) activation, while dopamine's effect involved both PKC and protein kinase A (PKA) pathways.
  • The study concluded that there are distinct signaling mechanisms for PTH and dopamine in regulating phosphate transport, and that MAPK activation does not play a critical role in this inhibition.
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There is increasing evidence that mammalian urinary tract epithelial cells utilize membrane channels and transporters to transport solutes across their apical (luminal) and basalateral membranes to modify solute concentrations in both cell and urine. This study investigates the expression, localization, and regulation of the ROMK (K(ir) 1.1) potassium channels in rat and dog ureter and bladder tissues.

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Sodium-hydrogen exchanger regulatory factor-1-deficient (NHERF-1(-/-)) mice demonstrate increases in the urinary excretion of phosphate, calcium, and uric acid associated with interstitial deposition of calcium in the papilla of the kidney. These studies examine the role of NHERF-1 in the tubular reabsorption of uric acid and regulation of mouse urate transporter 1 (mURAT1), a newly described transporter that is responsible for the renal tubular reabsorption of uric acid. In primary cultures of mouse renal proximal tubule cells, uric acid uptake was significantly lower in NHERF-1(-/-) cells compared with wild-type cells over a large range of uric acid concentrations in the media.

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Herpes simplex virus type 2 (HSV-2) infection commonly causes meningitis and genital herpes. We describe a rare case of brain stem encephalitis with cutaneous manifestations attributable to HSV-2 infection in a patient with HIV infection.

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