Publications by authors named "Marc Bohils"
The pulmonary microbiome has emerged as a significant factor in respiratory health and diseases. Despite the sterile conditions maintained during lung perfusion (EVLP), the use of antibiotics in the perfuse liquid can lead to dynamic changes in the lung microbiome. Here, we present the design of a study that aims to investigate the hypothesis that EVLP alters the lung microbiome and induces tissue inflammation.
View Article and Find Full Text PDFThe transplant community is focused on prolonging the preservation time of kidney grafts to allow for long-distance kidney graft transportation, assess the viability of marginal grafts, and optimize a platform for the translation of innovative therapeutics to clinical practice, especially those focused on cell and vector delivery to organ conditioning and reprogramming. We describe the first case of feasible preservation of a kidney from a donor after uncontrolled circulatory death over a 73-h period using normothermic perfusion and analyze hemodynamic, biochemical, histological, and transcriptomic parameters for inflammation and kidney injury. The mean pressure and flow values were 71.
View Article and Find Full Text PDFArticle Synopsis
- The purpose of the study was to create an active registry for patients with severe brain damage in the emergency room, aimed at identifying potential organ donors based on their clinical condition and progression.
- During a one-year study, 166 patients were evaluated, with about 46% identified as possible organ donors, leading to 37 actual organ donations, reflecting a 22.3% donation rate from the initial patient group.
- The registry improved the ability to detect and follow up with potential donors, resulting in various organs and tissues being made available for transplantation.
Background And Objective: The demand of tissue for transplants requires a continuous effort in detecting potential donors and assessing the causes of death. We aimed to assess the capacity to optimise tissue donation rates with the implementation of an active detection system of hospital deaths alongside a comprehensive assessment of the causes of death according to current international and local tissue banks' standards.
Material And Method: An early and pro-active detection programme of hospital deaths was implemented in 2002.