Publications by authors named "Marc A Siemonsma"
Background: The strength of intestinal anastomoses is relatively low in the first days after operation, possibly as a result of localized degradation of the supporting matrix by enzymes from the matrix metalloproteinase (MMP) family. The aim of this study was to examine whether doxycycline, a drug known to inhibit MMP activity, could enhance anastomotic strength.
Methods: Male Wistar rats received anastomoses in both ileum and colon.