Publications by authors named "Marc A Leroy"
Article Synopsis
- Disease emergence is increasing due to global changes, making it crucial to understand how host populations adapt rapidly, particularly in the context of Pacific oyster mortality syndrome (POMS).
- The study used (epi)genome-wide association mapping to reveal that oysters exposed to POMS showed signs of genetic and epigenetic selection, particularly in genes related to immunity.
- Results indicated that about one-third of the phenotypic variation in response to POMS could be attributed to interactions between genetic and epigenetic factors, highlighting the significant role of both in rapid adaptation to infectious diseases.
Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide.
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