Publications by authors named "Marble Manuwa"
Introduction: Immunoinformatic tools can be used to predict schistosome-specific B-cell epitopes with little sequence identity to human proteins and antigens other than the target. This study reports an approach for identifying schistosome peptides mimicking linear B-cell epitopes using in-silico tools and peptide microarray immunoassay validation.
Method: Firstly, a comprehensive literature search was conducted to obtain published schistosome-specific peptides and recombinant proteins with the best overall diagnostic performances.
Article Synopsis
- Traditional tests for schistosome infections are not very effective, especially with low parasite loads, prompting a search for better diagnostic proteins and peptides.
- The review followed established guidelines and searched multiple databases, finding promising recombinant and chimeric proteins with high sensitivity and specificity for detecting schistosomiasis.
- The tetraspanin CD63 antigen showed the best performance for S. haematobium, while peptide Smp_150390.1 excelled for S. mansoni, suggesting that multi-peptide approaches could significantly enhance diagnostic accuracy.