Publications by authors named "Marah Bakhtan"
Article Synopsis
- Understanding how genetic programs influence neuron classification is crucial for nervous system development, with neurons categorized into commissural (crossing midline) and ipsilateral (not crossing) types.
- We identified transcription factors Nhlh1 and Nhlh2 as key regulators controlling laterality in commissural axons in mice, mediating the expression of Robo3, a guidance molecule.
- Additionally, Isl1, found in ipsilateral neurons, inhibits Robo3 induction by Nhlh1/2, highlighting a complex interplay between global mechanisms and specific neuron regulators in determining axon paths.
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