Airway and serum adipokines after allergen and diesel exposure in a controlled human crossover study of atopic adults.

Adipokines are mediators released from adipose tissue. These proteins are regarded as active elements of systemic and pulmonary inflammation, whose dysregulation can alter an individual's risk of developing allergic lung diseases. Despite this knowledge, adipokine responses to inhaled stimuli are poorly understood.

The transcription factor Myt3 acts as a pro-survival factor in β-cells.

Aims/hypothesis: We previously identified the transcription factor Myt3 as specifically expressed in pancreatic islets. Here, we sought to determine the expression and regulation of Myt3 in islets and to determine its significance in regulating islet function and survival.

Methods: Myt3 expression was determined in embryonic pancreas and adult islets by qPCR and immunohistochemistry.