Publications by authors named "Mara L Paterson"
Although a variety of acid-generating molecules have been developed, the formation of toxic byproducts and the need for light-activation or temperatures that may be incompatible with physiological conditions leave room for the optimization of biocompatible acid-generators. Herein, we report 4-hydroxybenzyl chloride derivatives that generate hydrochloric acid via hydrolysis at the benzylic position at room temperature in the absence of light. Utilizing the acetal protected 4-hydroxybenzyl chloride scaffold, we access a myriad of compounds that generate acid at different rates.
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- - The study focuses on the phase behavior of crosslinked hydrogels, highlighting their ability to switch between dehydrated and hydrated states based on temperature changes, which affects water absorption and release.
- - A novel hydrogel system is introduced that can change its volume in response to carbon dioxide (CO) exposure, allowing for significant swelling (up to fivefold) and temperature shifts of up to 8.6 °C.
- - The findings suggest potential applications in drug delivery, as the hydrogel's phase transitions can be precisely tuned through its composition to suit specific uses, promoting further exploration in smart material development.
A major challenge in developing recyclable polymeric materials is the inherent conflict between the properties required during and after their life span. In particular, materials must be strong and durable when in use, but undergo complete and rapid degradation, ideally under mild conditions, as they approach the end of their life span. We report a mechanism for degrading polymers called cyclization-triggered chain cleavage (CATCH cleavage) that achieves this duality.
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