Publications by authors named "Mara Curaba"
Article Synopsis
- * Various vitrification solutions and methods, often adapted from embryo and oocyte procedures, have shown differing results across species; however, recent findings suggest vitrification may provide equal or better outcomes compared to traditional freezing.
- * Understanding the impact of vitrification solutions on ovarian tissue, particularly preantral follicles, and employing diverse methods to evaluate tissue functionality and oocyte quality are crucial for validating the positive results observed in vitrification studies.
Objective: To assess vitrification of prepubertal human testicular tissue in vitro.
Design: Case report.
Setting: Academic research unit.
Objective: To compare cryopreservation of prepubertal testicular tissue after vitrification (V) and slow-freezing (SF).
Design: Prospective experimental study.
Setting: Academic research unit.
Background: Fertility in adult life may be severely impaired by gonadotoxic therapies. For young boys who do not yet produce spermatozoa, cryopreservation of immature testicular tissue (ITT) is an option to preserve their fertility, albeit still experimental. This paper covers current options for ITT cryopreservation and fertility restoration.
View Article and Find Full Text PDFTen male subjects affected by sickle cell anemia (SCA) were studied to evaluate the long-term effects of therapies on their fertility. Their ages ranged from 18 to 34 years (median: 32 years). Four subjects were treated by hydroxyurea (HU) and 6 by hematopoietic stem cell transplantation (HSCT).
View Article and Find Full Text PDFBackground: Preservation of the male germ line in prepubertal boys undergoing gonadotoxic treatment is a crucial consideration in terms of their future quality of life. As these patients do not yet produce spermatozoa for freezing, only immature tissue is available for storage. We studied the survival, proliferation and differentiation capacity of spermatogonia after cryopreservation and long-term transplantation of immature testicular tissue pieces.
View Article and Find Full Text PDFBackground: Fertility preservation has become an urgent clinical requisite for prepubertal male cancer patients undergoing gonadotoxic treatment. As these patients do not yet produce spermatozoa for freezing, only immature tissue is available for storage. We studied the survival and proliferative activity of spermatogonia and Sertoli cells after cryopreservation of cryptorchid testicular tissue pieces followed by xenografting for 21 days.
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