Publications by authors named "Mar Rodriguez-Santamaria"
Article Synopsis
- - Aging leads to a decline in bodily functions and the development of various diseases, but environmental factors like lifestyle choices can impact this decline and promote healthier aging.
- - Research conducted on male mice reveals changes in the hippocampus as they age, including inflammation and issues with how mRNA is processed, along with modifications to their genetic structure.
- - By providing enriched environments for these mice, many age-related changes were reversed, particularly in pathways linked to brain support cells, suggesting that lifestyle choices can have a significant effect on aging at a molecular level.
Targeting epigenetic mechanisms has emerged as a potential therapeutic approach for the treatment of kidney diseases. Specifically, inhibiting the bromodomain and extra-terminal (BET) domain proteins using the small molecule inhibitor JQ1 has shown promise in preclinical models of acute kidney injury (AKI) and chronic kidney disease (CKD). However, its clinical translation faces challenges due to issues with poor pharmacokinetics and side effects.
View Article and Find Full Text PDFMithramycin delivery systems to develop effective therapies in sarcomas.
J Nanobiotechnology
September 2021
Background: Sarcomas comprise a group of aggressive malignancies with very little treatment options beyond standard chemotherapy. Reposition of approved drugs represents an attractive approach to identify effective therapeutic compounds. One example is mithramycin (MTM), a natural antibiotic which has demonstrated a strong antitumour activity in several tumour types, including sarcomas.
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