Publications by authors named "Mar Reano-Martos"
The resolution of inflammation is a complex process that is critical for removing inflammatory cells and restoring tissue function. The dysregulation of these mechanisms leads to chronic inflammatory disorders. Platelets, essential cells for preserving homeostasis, are thought to play a role in inflammation as they are a source of immunomodulatory factors.
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- Scientists are trying to understand why some people with severe allergies have ongoing inflammation in their bodies, but it’s still a mystery.
- They studied T cells (a type of immune cell) from allergic asthma patients and found that those with severe allergies showed different behaviors and changes in their genes compared to mild patients and healthy people.
- The severe allergic patients had fewer working genes related to energy production, but more genes that cause inflammation, suggesting their immune system isn't regulating itself properly.
Background: Mechanisms causing the onset and perpetuation of inflammation in severe allergic patients remain unknown. Our previous studies suggested that severe allergic inflammation is linked to platelet dysfunction.
Methods: Platelet-rich plasma (PRP) and platelet-poor plasma (PPP) samples were obtained by platelet-apheresis from severe (n = 7) and mild (n = 10) allergic patients and nonallergic subjects (n = 9) to perform platelet lipidomics by liquid chromatography coupled to mass spectrometry (LC-MS) and RNA-seq analysis.
Background: In previous studies with peripheral blood cells, platelet factors were found to be associated with severe allergic phenotypes. A reliable method yielding highly concentrated and pure platelet samples is usually not available for immunological studies. Plateletpheresis is widely used in the clinics for donation purposes.
View Article and Find Full Text PDFAnaphylaxis induced by fosfomycin.
Ann Allergy Asthma Immunol
September 2010
Work-related anaphylaxis to wasp sting.
Occup Med (Lond)
December 2007
Objective: To describe the frequency and epidemiological features of wasp venom allergy in the workplace.
Methods: Retrospective review of 98 adult patients (age 18-65) who suffered an anaphylactic reaction to a wasp sting. Patients were asked about reactions during working hours.