Publications by authors named "Mar Collado-Perez"
Int J Mol Sci
November 2024
Article Synopsis
- Several neurodegenerative diseases, like Huntington's and Parkinson's, are linked to harmful long polyglutamine (polyQ) tracts.
- Researchers explored the effects of erucin (ERN), a natural compound found in rocket salad, and sulforaphane (SFN) in broccoli, on polyQ toxicity.
- The study found that ERN protects against polyQ-induced toxicity by working through the AMPKα2 enzyme and the FOXO transcription factor, and also showed potential for reducing α-synuclein aggregates in Parkinson's disease, suggesting further research in mouse models is needed to assess its protective effects in humans.
