Publications by authors named "Mar Blanes-Martinez"
Article Synopsis
- - A study evaluated the effectiveness and safety of dupilumab for treating bullous pemphigoid in elderly patients, with a focus on those who typically have other health issues that make standard treatments unsuitable.
- - The results showed that 53.4% of patients achieved complete remission within 4 weeks and 95.7% by week 52, with a significant reduction in itchiness and a dramatic decrease in the need for corticosteroids.
- - The treatment was found to be safe, with most adverse events being mild, and factors like shorter disease duration and exclusive skin involvement were linked to better treatment responses.
Article Synopsis
- Bullous pemphigoid (BP) is a common autoimmune blistering condition usually affecting older adults with various health issues, traditionally treated with corticosteroids, which have numerous side-effects.* -
- A study assessed the use of omalizumab, an IgE-targeting monoclonal antibody, for treating BP in patients who had previously used other therapies, finding that 83% of patients responded to the treatment.* -
- The results showed that omalizumab was well-tolerated with no reported side-effects, highlighting its potential as a safer and effective alternative for BP treatment compared to conventional therapies.*
Cutaneous immune-related adverse events: incidence rates, risk factors and association with extracutaneous toxicity - a prospective study of 189 patients treated with checkpoint inhibitors at a Spanish tertiary care hospital.
Clin Exp Dermatol
August 2024
Background: Clinicians are increasingly prescribing immune checkpoint inhibitors (ICIs) to treat cancer, but the real-world incidence, characteristics and risk factors of cutaneous immune-related adverse events (cirAEs) are unclear.
Objectives: To determine the incidence, features and risk factors of cirAEs and to measure their possible association with extracutaneous toxicity.
Methods: We conducted a prospective observational study in a Spanish tertiary care hospital, including people who started an ICI between March 2020 and May 2022.
A 4-year-old girl presented with a 2-month history of round, hypopigmented, slightly scaly patches measuring 1-6 cm and encircled by an erythematous halo, first appearing on the lower limbs then spreading to the whole body. Three biopsies were taken as the condition progressed, each showing a lymphocytic infiltrate affecting a medium-sized artery at the dermal-subcutaneous junction, with a concentric fibrin ring. These findings are characteristic of lymphocytic thrombophilic arteritis (LTA).
View Article and Find Full Text PDFChilblain-like acral lesions have been identified in some coronavirus disease 2019 (COVID-19) patients. It has been suggested that these pseudo-chilblains could be a specific marker of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Most patients with these lesions have had negative polymerase chain reactions (PCRs), but some authors believe serology tests are likely to give positive results.
View Article and Find Full Text PDF